| 高效液相色谱法测定消毒饮优化方胶囊中的异嗪皮啶 |
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| 引用本文： | 王绍龙,付书婕,巫玲玲,农慧亮,蒋伟哲,吴洪文.高效液相色谱法测定消毒饮优化方胶囊中的异嗪皮啶[J].药物评价研究,2014(1):58-60. |
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| 作者姓名： | 王绍龙 付书婕 巫玲玲 农慧亮 蒋伟哲 吴洪文 |
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| 作者单位： | [1]广西医科大学药学院,广西南宁530021 [2]柳州市工人医院,广西柳州545005 |
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| 基金项目： | 基金项目：广西科学研究与技术开发计划课题（桂科攻11107009.2-4）;广西壮族自治区中医药科技专项课题（GZYZ1125）：广西教育厅校地校企共建科技创新平台项目（桂教科研[201119号）;广西教育厅校地校企共建科技创新平台项目（桂教科研[2013]8号-3） |
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| 摘 要： | 目的建立消毒饮优化方胶囊中异嗪皮啶的HPLC测定方法。方法采用phenomenexSynergi4UFusion—RP80A柱（250mm×4．60mm，4μm），流动相为乙腈-1％磷酸（20：80），体积流量为1．0mL／min，柱温为40℃，检测波长为342am。结果异嗪皮啶进样量在0．1000～1．0000岭与峰面积呈良好的线性关系（r=0．9999），平均回收率为95．04％，RSD=1．84％（n=6）。结论该方法操作简便、准确、专属性强、重复性好，可用于消毒饮优化方胶囊中异嗪皮啶的含量测定。
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| 关 键 词： | 高效液相色谱法 消毒饮优化方胶囊 异嗪皮啶 含量测定 |
Determination of isofraxidin in Optimizing Xiaoduyin Capsules by HPLC |
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| WANG Shao-long,FU Shu-jie,WU Ling-ling,NONG Hui-liang,JIANG Wei-zhe,WU Hong-wen.Determination of isofraxidin in Optimizing Xiaoduyin Capsules by HPLC[J].Drug Evaluation Research,2014(1):58-60. |
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| Authors: | WANG Shao-long FU Shu-jie WU Ling-ling NONG Hui-liang JIANG Wei-zhe WU Hong-wen |
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| Institution: | 1. Pharmaceutical College, Guangxi Medical University, Nanning 530021, China 2. Liuzhou Worker＇s Hospital, Liuzhou 545005, China |
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| Abstract: | Objective To establish a method for the content determination of isofraxidin in Optimizing Xiaoduyin Capsules. Methods The HPLC was performed on the phenomenex Synergi 4 u Fusion-RP 80A colunm （250mm×4.60mm,4μm） with the mobile phase of acetonitdle-1% phosphoric acid （20：80）; The flow rate was 1.0 mL/min, the column temperature was 40℃, and the detection wavelength 342 nm. Results The sample size of isofraxidin during the range of 0.100 0--1.000 0 μg showed a good linear relation with the peak area （r = 0.999 9）, and the average recovery rate was 95.04%, with RSD of 1.84% （n = 6）. Conclusion The method is simple, reliable, and specific, with good reproducibility, and could be used to determine the content of isofraxid in Optimizing Xiaoduyin Capsules. |
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| Keywords: | HPLC Optimizing Xiaoduyin Capsules isofraxidin content detemination |
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