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Dopamine D4 receptor gene polymorphism and personality traits in healthy volunteers |
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| Authors: | M.-L. Persson D. Wassermann T. Geijer A. Frisch R. Rockah E. Michaelovsky A. Apter A. Weizmann E. G. Jönsson H. Bergmann |
| Affiliation: | (1) National and Stockholm County Council Centre for Suicide Research and Prevention, National Institute for Psychosocial Factors and Health and Department of Public Health Sciences, Karolinska Institutet, Box 230, SE-17177 Stockholm, Sweden, e-mail: Maj-Liz.Persson@neurotec.ki.se, SE;(2) Department of Clinical Neuroscience, Occupational Therapy and Elderly Care Research, Section of Psychiatry, Karolinska Institutet, SE-14186 Stockholm, Sweden, SE;(3) Felsenstein Medical Research Center, Rabin Medical Center and Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel, IL;(4) Geha Psychiatric Hospital, Rabin Medical Center, Petah-Tikva, and Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel, IL;(5) Department of Clinical Neuroscience, Psychiatry Section, Karolinska Institutet, Stockholm, Sweden, SE;(6) Clinical Alcohol and Drug Addiction Research Section, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden, SE |
| Abstract: | An association between long alleles of a variable number tandem repeat (VNTR) polymorphism in the dopamine receptor D4 gene and the extraversion related personality traits Excitement and Novelty Seeking has been reported in healthy subjects. In an attempt to replicate the previous findings, 256 healthy Caucasian volunteers were analysed for a potential relationship between the dopamine receptor D4 exon III VNTR polymorphism and Extraversion as assessed by the Revised Neo Personality Inventory (NEO PI-R). The present study did not yield evidence for an association between Extraversion and the dopamine receptor D4 polymorphism. Received: 8 June 1999 / Accepted: 4 April 2000 |
| Keywords: | Dopamine receptor D4 Genetics Personality inventory Polymorphism Excitement-Seeking |
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