| 胆囊癌中基质金属蛋白酶-9、粘附分子CD44变构体6表达及其临床意义 |
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| 引用本文： | 张云锋,王作仁,牛新捷,王林,李恒力.胆囊癌中基质金属蛋白酶-9、粘附分子CD44变构体6表达及其临床意义[J].中华实验外科杂志,2002,19(5):405-406. |
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| 作者姓名： | 张云锋 王作仁 牛新捷 王林 李恒力 |
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| 作者单位： | 1. 710061,西安交通大学第一医院肝胆外科
2. 西安交通大学医学院病理学教研室 |
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| 摘 要： | 目的 研究胆囊癌中基质金属蛋白酶-9（MMP-9），粘附分子CD44变构体6（CD44v6)的表达情况及其临床意义。方法 应用免疫组织化学Env ision二步法测定46例胆囊癌（GBC）和12例慢性结石性胆囊炎中MMP-9，CD44v6表达。结果 MMP-9，CD44v6在胆囊癌组织中阳性表达率分别为78.26%,71.74%,MMP-9,CD44v6表达与胆囊癌分化程度，临床分期，淋巴结转移，术后生存率有关。结论 检测MMP-9，CD44v6的表达有望成为判断胆囊癌淋巴结转移，病变发展以及评估预后的客观指标。
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| 关 键 词： | 胆囊癌 基质金属蛋白酶－9 粘附分子 CD44变构体6 免疫组织化学 |
| 修稿时间： | 2001年11月26 |
Expression of MMP-9 and CD44v6 in gallbladder carcinoma and implication |
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| ZHANG Yunfeng,WANG Zuoren,NIU Xinjie,et al..Expression of MMP-9 and CD44v6 in gallbladder carcinoma and implication[J].Chinese Journal of Experimental Surgery,2002,19(5):405-406. |
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| Authors: | ZHANG Yunfeng WANG Zuoren NIU Xinjie |
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| Institution: | ZHANG Yunfeng,WANG Zuoren,NIU Xinjie,et al. Department of Hepatobiliary Surgery,First Hospital of Xi'an Jiaotong University,Xi'an 710061,China |
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| Abstract: | Objective To investigate the clinical implication of MMP 9, CD44v6 protein expression in gallbladder carcinoma (GBC).Methods The immunohistochemical Envision technique was adopted for detecting the MMP 9, CD44v6 protein expression in 46 cases of GBC and 12 cases of chronic cholecystitis.Results The positive rate of MMP 9 and CD44v6 expression in gallbladder carcinoma was 78.26% and 71.74% respectively. The positive expression of MMP 9 and CD44v6 was correlated with the pathologic differentiation, clinic staging, lymph node metastasis and postoperation survival rate.Conclusion Expression of MMP 9 and CD44v6 might be served as an objective indicator for lymph node metastatic potency, tumor progress and prognosis in gallbladder carcinoma. |
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| Keywords: | Gallbladder neoplasm Matrix metalloproteinase 9 CD44 antigens Immunohistochemistry |
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