| 缺血/再灌注损伤时细胞周期调控的研究进展 |
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| 引用本文： | 杜秋国,高建虎,徐志广.缺血/再灌注损伤时细胞周期调控的研究进展[J].医学综述,2012,18(16):2537-2539. |
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| 作者姓名： | 杜秋国 高建虎 徐志广 |
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| 作者单位： | 广州军区武汉总医院普外科,武汉,430070;南方医科大学,广州,510515 |
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| 基金项目： | 国家自然科学基金(81170420) |
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| 摘 要： | 体内许多器官,如肾、脑、肝等都可发生缺血/再灌注损伤(IRI)。IRI后,细胞周期检验点将受损伤的细胞阻滞在相应的位置进行修复,若修复成功,细胞进入下一个周期,否则发生凋亡。在细胞周期调控中,细胞周期蛋白、细胞周期蛋白依赖性激酶、细胞周期蛋白依赖性激酶抑制因子三者非常重要。现对IRI时细胞周期蛋白、细胞周期蛋白依赖性激酶、细胞周期依赖性激酶抑制因子三者调控细胞周期的研究进展进行综述。
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| 关 键 词： | 缺血/再灌注损伤 细胞周期蛋白 细胞周期蛋白依赖性激酶 |
Research Progress of the Cell Cycle Regulation in Ischemia-Reperfusion Injury |
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| DU Qiu-guo
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GAO Jian-hu
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XU Zhi-guang.Research Progress of the Cell Cycle Regulation in Ischemia-Reperfusion Injury[J].Medical Recapitulate,2012,18(16):2537-2539. |
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| Authors: | DU Qiu-guo GAO Jian-hu XU Zhi-guang |
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| Institution: | 1.(1.Department of General Surgery,Wuhan General Hospital of Guangzhou Military Command,Wuhan 430070,China;2.Southern Medical University,Guangzhou 510515,China) |
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| Abstract: | Ischemia-reperfusion injury(IRI)exists in many organs including kidney,brain,liver,and so on.In ischemia-reperfusion injury,cell cycle checking point blocks the injured cells in corresponding positions for repair,if successful,cells will go into the next cycle;otherwise,apoptosis happens.Cyclins,cyclin-dependent kinases(CDK)and cyclin-kinase inhibitor(CKI)are very important for the cell cycle regulation.Here is to make a review on the study progresses of the cell cycle regulation by cyclins,CDK and CKI in IRI. |
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| Keywords: | Ischemia-reperfusion injury Cyclins Cyclin-dependent kinases |
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