| 半枝莲多糖对C26荷瘤小鼠血清Th1/Th2亚群细胞因子的影响 |
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| 引用本文： | 叶华,吴琼,郭蒙,朱宇珍,郑学宝.半枝莲多糖对C26荷瘤小鼠血清Th1/Th2亚群细胞因子的影响[J].癌症进展,2013,11(1):68-70,81. |
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| 作者姓名： | 叶华 吴琼 郭蒙 朱宇珍 郑学宝 |
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| 作者单位： | 广东医学院天然药物研究与开发重点实验室,湛江,524023;广东医学院天然药物研究与开发重点实验室,湛江524023;广东医学院药理教研室,湛江524023 |
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| 基金项目： | 国家自然科学基金(30772701);广东省科技计划项目(2011B03170065);广东省建设中医药强省项目(20112144);湛江市科技攻关项目(2009C3104003) |
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| 摘 要： | 目的观察半枝莲多糖(scutellaria barbata polysaccharides,SPS)对C26荷瘤小鼠血清Th1/Th2亚群细胞因子的影响。方法建立C26结肠癌小鼠移植瘤模型,SPS作用10天后,通过眼眶静脉采血,分离血清,ELISA法测定Th1亚群细胞因子IFN-γ、IL-2和Th2亚群细胞因子IL-4、IL-10的含量。结果 SPS 100 mg·kg~(-1)·d~(-1)、200mg·kg~(-1)·d~(-1)剂量组治疗组与模型组比较,IL-4和IL-10水平明显下降,IFN-γ和IL-2水平明显上升,差异有统计学意义。结论 SPS可以调节荷瘤小鼠Th1/Th2平衡。
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| 关 键 词： | 半枝莲多糖 Th1/Th2细胞因子 肿瘤 |
Effect of Scutellaria barbata polysaccharides on Th1/Th2 cytokines in C26 tumor bearing mice |
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| YE Hua,WU Qiong,GUO Meng,ZHU Yu-zhen,ZHENG Xue-bao.Effect of Scutellaria barbata polysaccharides on Th1/Th2 cytokines in C26 tumor bearing mice[J].Oncology Progress,2013,11(1):68-70,81. |
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| Authors: | YE Hua WU Qiong GUO Meng ZHU Yu-zhen ZHENG Xue-bao |
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| Institution: | 1#) 1 Key Laboratory for Research and Development of Natural Drugs,2 Department of Medicine, Guangdong Medical College,Zhanjiang 524023,China |
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| Abstract: | Objective To study the effect of scutellaria barbara polysaccharides on Th1/Th2 cytokines in C26 tumor beating mice. Method The C26 tumor bearing mouse model was established. The blood cytokines, including IFN-γ, IL-2, IL-4 and IL-10, were detected by ELISA assay after giving SPS 10 days. Result Compared with model group, 100, mg· kg-1· d-1 and 200 mg·kg-1·d-1 SPS reduced IL-4 and IL-10 levels, and increased IFN-γ and IL-2 levels significantly. Conclusion SPS can regulate the Th1/Th2 balance in tumor-beating mice. |
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| Keywords: | cutellaria barbara polysaccharides Th1/Th2 cytokines tumor |
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