Central amine metabolism in Alzheimer's disease: In vivo relationship to cognitive deficit |
| |
Authors: | JJohn Mann Michael Stanley Andreas Neophytides Mony J de Leon Steven H Ferris Samuel Gershon |
| |
Institution: | 1. Payne Whitney Clinic, New York Hospital-Cornell University Medical College 525 East 68th Street, New York, NY USA;2. Department of Psychiatry, New York University Medical Center, 550 First Avenue, New York, NY USA;3. Department of Neurology, New York University Medical Center, 550 First Avenue, New York, NY USA |
| |
Abstract: | Levels of the amine metabolites homovanillic acid (HVA) and methoxyhydroxyphenylglycol (MHPG) were measured in the cerebrospinal (CSF) fluid of drug-free patients with Alzheimer's disease and compared to levels in a group of controls. No significant differences were found in CSF HVA and MHPG, although the Alzheimer's group was severely demented. Platelet monoamine oxidase (MAO) enzyme kinetics were measured and did not differ between controls and Alzheimer patients. The degree of dementia did not show any significant correlation with the levels of HVA or MHPG. It was concluded that, unlike previous reports in the literature, the dementia of Alzheimer's disease was not related to changes in central catecholamine metabolism nor was it associated with increased platelet MAO activity. |
| |
Keywords: | Alzheimer's disease Cerebrospinal fluid Homovanillic acid Methoxyhydroxyphenylglycol Platelet monoamine oxidase activity CT scan |
本文献已被 ScienceDirect 等数据库收录! |
|