Genetic Polymorphisms of LMP/TAP Gene and Hepatitis B Virus Infection Risk in the Chinese Population |
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Authors: | Changqing Xu Suxia Qi Lei Gao Hong Cui Meiqiang Liu Hongli Yang Kun Li Bangwei Cao |
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Affiliation: | (1) Department of Gastroenterology, Shandong Provincial Qianfoshan Hospital, Jinan, Shandong Province, China;(2) Department of Emergency, Qingdao Municipal Hospital, Qingdao, Shandong Province, China;(3) Department of Anti-infection & Institute of Clinical Pharmacology, Peking University First Hospital, #1 Xi An Men Da Jie St. Western District, Beijing, 100034, P. R. China |
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Abstract: | Despite the availability of effective vaccines, hepatitis B virus (HBV) infection is still commonly seen worldwide. Several reports show that the human major histocompatability complex (MHC) systems were involved in the elimination of HBV via the restrictive antigen-processing pathway. We investigate whether LMP/TAP gene polymorphisms coded by MHC-II region were associated with HBV infection. A total of seven polymorphisms of LMP/TAP gene were identified by polymerase chain reaction (PCR) restriction fragment length polymorphism (RFLP) assays. Three hundred fifty-six patients and 326 unrelated healthy volunteers were included in the case-control study. Of the seven polymorphisms, three of which (LMP7 codons 145, TAP1 codons 637, and TAP2 codons 651) were observed to have statistically significant association with HBV infection (P < 0.05). We analyzed the three-locus haplotype constructed with three such polymorphisms and found that the frequency of haplotypes D and E increased significantly in patients, in comparison with that in controls (OR = 3.57, 95% CI: 2.09–6.12, P < 0.001; OR = 2.74, 95% CI: 1.35–5.56, P = 0.005, respectively). The results imply that LMP7-145, TAP1-637, and TAP2-651 sites were associated with the risk of HBV infection. Haplotypes D and E might be involved in the development of HBV infection. These data suggest a potential role of LMP/TAP gene as a candidate gene for susceptibility to HBV infection. |
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Keywords: | Hepatitis B virus (HBV) LMP/TAP Polymorphism |
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