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Successful treatment of a pregnant woman with Philadelphia chromosome-positive acute lymphoblastic leukemia |
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| Authors: | Yuki Nakajima Hideyuki Kuwabara Yukako Hattori Rika Ohshima Rika Sakai Masakazu Kitagawa Naoto Tomita Yoshiaki Ishigatsubo Shin Fujisawa |
| Affiliation: | 1. Department of Hematology, Yokohama City University Medical Center, Minami-ku Urafune-chou 4-57, Yokohama, Kanagawa, 232-0024, Japan 2. Department of Medical Oncology, Kanagawa Cancer Center, Yokohama, Japan 3. Perinatal Center, Yokohama City University Medical Center, Yokohama, Japan 4. Department of Internal Medicine and Clinical Immunology, Yokohama City University Graduate School of Medicine, Yokohama, Japan |
| Abstract: | The management of acute leukemia during pregnancy is challenging. Delays in treatment for acute leukemia can adversely affect maternal prognosis, but chemotherapy during pregnancy may induce severe adverse effects on the fetus. Here, we report a case of a pregnant woman with Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ALL) who underwent remission induction therapy and successfully delivered a live infant after chemotherapy. The case is a 36-year-old woman diagnosed with Ph+ALL in the 27th week of pregnancy. She underwent remission induction therapy including daunorubicin, vincristine, cyclophosphamide, and prednisolone. Imatinib was not used in the induction therapy. She delivered the infant after one course of chemotherapy. The infant and the patient are both alive now, without any major complications. |
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