| Implantation of xenogeneic bone combined with recombinant human bone morphogenetic protein-2 into bone defect—An scanning electron microscopic study |
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| 引用本文： | 王常勇,毛天球,王会信,赵明,朱萧玲.Implantation of xenogeneic bone combined with recombinant human bone morphogenetic protein-2 into bone defect—An scanning electron microscopic study[J].中国人民解放军军医大学学报,1997(2). |
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| 作者姓名： | 王常勇 毛天球 王会信 赵明 朱萧玲 |
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| 作者单位： | Department of Maxillofacial surgery，Stomatological college，Fourth Military Medical University，Xi'an，710032 Institute of Basic Medical Sciences，Academy of Military Medical Sciences，Bei |
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| 摘 要： | Xenogeneicbonehasagreatpotentialforgraftingowingtoitsunlimitedsourcesandsimple,economicalcharacters'However,theimmunere-jectionevokedbyxenograftrestrictsitsclinicalap-plication.Howtoeliminatetheantigenicityofthegraftwhilepreserveitsosteoinductivepropertiesisthekeytosuccessfulgraftingandisalsothepur-poseofthisstudy.Thechemicallytreatedsheepcancellousbonehasasuitableframeworkformechanicalsupportandisagoodcarrierofbonemorphogeneticprotein(BMP)withattenuatedantigenicity,butitlacksosteoinductivefa…
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Implantation of xenogeneic bone combined with recombinant human bone morphogenetic protein-2 into bone defect An scanning electron microscopic study |
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| Wang Changyong,Mao Tianqiu,Wang Huixin,Zhao Ming,Zhu Xiaoling.Implantation of xenogeneic bone combined with recombinant human bone morphogenetic protein-2 into bone defect An scanning electron microscopic study[J].Journal of Medical Colleges of PLA(China),1997(2). |
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| Authors: | Wang Changyong Mao Tianqiu Wang Huixin Zhao Ming Zhu Xiaoling |
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| Abstract: | To determine the ability of a new type of composite xenogeneic bone grafting to repair bone defect. Methods: The new type of composite xenogeneic bone was obtained by combining the chemically treated cance1lous bone with recombinant human bone morphogenetic protein-2 (rhBMP-2). It was implanted on the bone defect of rabbit. Results: There was a large amount of new bone formation within the combined material and the amount was increasing as the time elapsed. In contrast, there was a lot of fibrous tissue with a little new bone formed on the area of the bone defect when the treated cancellous bone was implanted alone. Conclusion: The results imply that the rhBMP-2 plays a very important role in new bone formation and the composite xenogeneic bone appear to be an ideal material for repair of bone defect. |
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| Keywords: | recombinant human bone morphogenetic protein-2 bone transplantation cancellous bone |
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