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| TRH对兔急性颅脑损伤后脑组织自由基反应的影响 | |
| 引用本文： | 牛光明,苏芳忠,杨涛,顾秀娟,薛德麟,苏玉林.TRH对兔急性颅脑损伤后脑组织自由基反应的影响[J].郑州大学学报(医学版),2001,36(6):685-687. |
| 作者姓名： | 牛光明 苏芳忠 杨涛 顾秀娟 薛德麟 苏玉林 |
| 作者单位： | 1. 河南医科大学第二附属医院神经外科, 2. 郑州市第二人民医院外科, 3. 华中科技大学同济医学院附属同济医院神经外科, 4. 河南电力医院神经外科, |
| 摘 要： | 目的 :探讨促甲状腺素释放激素 (TRH)对急性实验性颅脑损伤后脑组织自由基反应的影响。方法 :30只家兔随机分为A、B、C 3组。A组和B组采用自由落体直接打击法建立兔急性实验性颅脑损伤模型 ,C组不致伤。A、B 2组致伤后 0 .5h分别给予TRH或等量生理盐水至伤后 4h。检测脑组织SOD、LPO ,采用干燥重量法测定脑含水量。结果 :与B组比较 ,A组损伤后脑组织中SOD活性增加 ,LPO含量及脑组织含水量减少 (P <0 .0 5 ) ;A组与B组致伤后 5min颅内压均较C组及伤前升高 (P <0 .0 5 ) ,且随时间延长 ,颅内压递增 ,但A组给药后颅内压增高速度明显减慢 (P <0 .0 5 )。结论 :TRH能够显著减轻兔急性实验性颅脑损伤后脑组织自由基反应 ,减轻脑水肿 |
| 关 键 词： | TRH 脑损伤 超氧化物歧化酶 脂质过氧化物 |
| 修稿时间： | 2001年7月10日 |
Effect of TRH on free radical reaction in the experimental brain in jury of rabbits |
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| NIU Guangming ,SU Fangzhong ,YANG Tao ,GU Xiujuan ,XUE Delin ,SU Yulin.Effect of TRH on free radical reaction in the experimental brain in jury of rabbits[J].Journal of Zhengzhou University: Med Sci,2001,36(6):685-687. | |
| Authors: | NIU Guangming SU Fangzhong YANG Tao GU Xiujuan XUE Delin SU Yulin |
| Institution: | NIU Guangming 1),SU Fangzhong 1),YANG Tao 2),GU Xiujuan 2),XUE Delin 3),SU Yulin 4) 1)Department of Neurosurgery,the Second Affiliated Hospital,Henan Medical University,Zhengzhou 450003 2)Department of Surgery,the Second |
| Abstract: | Aim: To investigate the effect of TRH on free radical reactions in brain tissues after acute experimental brain injury. Methods: The acute experimental rabbit brain injury model was established by direct hit with free falling objects.Thirty rabbits were randomly divided into 3 groups.Group A,the treatment group in which TRH was injected through veins to each rabbit.Group B,the control group in which the equal quantity of normal saline was injected as above.Group C was the sham control group.Rabbits in group A and B were killed 4 h after the injury.The contents of LPO,water and activity of SOD in brain tissues were measured. Results: The contents of LPO and water in brain tissue of group A were lower and the activity of SOD was higher than those of group B( P< 0.05).After the injury ICP rose rapidly and continuously with extending of injury in group A and B,but after TRH was given to group A ,the rising speed of ICP slowed down significantly( P <0.05). Conclusion: It is suggested that the effects of TRH on brain injury are suppression of free radical reaction and decreasing the content of water in brain tissues. |
| Keywords: | thyrotropin releasing hormone(TRH) brain injury superoxide dismutase(SOD) lipoperoxide(LPO) rabbit |
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