抗结核抗体检测及其结果分析

目的 探讨分别或组合检测LAM -IgG?TB -Dot?ICT对结核病的诊断价值?方法 抽取血清或留取胸?腹水?脑脊液?支气管灌洗液 ,同时进行LAM -IgG?TB -Dot?ICT三种方法 ,检测抗结核抗体?结果 菌 ( +)肺结核三者的阳性率分别为 4.5.3 %?63 5%?69.1 % ,三种检测方法同时均为 (+) 3.3.1 % ,任意两种检测方法组合阳性 2.37% ,二者相加总阳性率 56.8%?菌 ( -)肺结核三者的阳性率分别为 2.46%?3.93 %?3.95%?三种组合检测方法同时阳性 1.54 % ,任意两种检测方法组合阳性为 1.84 % ,二者相加阳性率达 3.38% ,与非结核组有显著性差异?菌 (+)肺结核和菌 (-)肺结核组分别有 2.53 %和 3.71 %三种方法同时检测抗体均为阴性?结论 抗结核抗体检测 ,特别是三种方法同时检测是结核病诊断和鉴别诊断的重要依据之一 ,但一些重症肺结核 ,伴有糖尿病等多种合并症者和老年肺结核阳性率低 ,另外结核性浆膜炎其抗体水平明显低于肺结核?

Anti-tuberculosis antibody test and result analysis

Objective Discuss the diagnostic value for tuberculosis with combination of three antibody test methods of LAM-IgG,TB-Dot,ICT.Methods Withdraw serum(pleural fluid,ascites,BALF,cerebrospinal fluid),and test TB antibodies simultaneously using LAM-IgG?TB-Dot?ICT methods.Results Bacillus positive pulmonary tuberculosis for the three methods was 45.3%?63.5% and 69.1% positive respectively,with 3 methods all positive 33.1% and any two of the three positive 23.7%,adding up to 56.8%.Bacillus negative pulmonary tuberculosis for the three methods was 24.6%?39.3% and 39.5% positive respectively,with all three positive 15.4% and any two of them positive 18.4%,adding up to 33.8%,significantly different compared with nontuberculosis group.For bacillus positive and negative pulmonary tuberculosis the three methods all failed to produce in 25.3% and 37.0% of both respectively.Conclusion Antituberculosis antibody test especially using 3 methods simutaneouely is one of the major basis for the tuberculosis diagnosis and differential diagnosis.But in some serious pulmonary tuberculosis patients,patients with complications such as diabetes mellitus and old pulmonary tuberculosis patiente the positive rate is low.In addition,the antibody level in tuberculosis serositis is significantly lower than in pulmonary tuberculosis.