| 2-BFI对EAE小鼠iNOS和COX-2 mRNA表达的影响 |
| |
| 引用本文： | 林福虹,郑荣远,王沛,王赵伟. 2-BFI对EAE小鼠iNOS和COX-2 mRNA表达的影响[J]. 中国神经免疫学和神经病学杂志, 2011, 18(1): 27-31. DOI: 10.3969/j.issn.1006-2963.2011.01.008 |
| |
| 作者姓名： | 林福虹 郑荣远 王沛 王赵伟 |
| |
| 作者单位： | 温州医学院附属第一医院神经内科,325000 |
| |
| 基金项目： | 国家自然科学基金资助项目，浙江省自然科学基金资助项目 |
| |
| 摘 要： | 目的探讨咪唑啉2受体(I2R)高选择性高亲和力配体2-BFI对实验性自身免疫性脑脊髓炎(EAE)小鼠诱导型一氧化氮合酶(iNOS)和环氧化酶-2(COX-2)mRNA表达的影响。方法使用髓鞘少突胶质细胞糖蛋白(MOG35-55)抗原诱导EAE小鼠模型。采用临床症状评分、病理学检查和反转录-聚合酶链反应(RT-PCR)观察完全福氏佐剂(CFA)对照组、EAE组和2-BFI干预组小鼠行为学、中枢炎性细胞浸润及iNOS和COX-2mRNA表达变化。结果 2-BFI干预组较EAE组临床症状明显减轻(P<0.01),中枢炎性细胞浸润显著减少(P<0.01),iNOS和COX-2的mRNA表达水平降低(P<0.05,P<0.01)。结论 I2R高选择性配体2-BFI对EAE小鼠具有一定保护作用,其作用机制可能与降低iNOS和COX-2 mRNA表达有关。
|
| 关 键 词： | 2-BFI 实验性自身免疫性脑脊髓炎 诱导型一氧化氮合酶 环氧化酶-2 |
Intervention effects of 2-BFI on iNOS and COX-2 mRNA In the cerebrum of mice with experimental autoimmune encephalomyelitis |
| |
| LIN Fu-hong,ZHENG Rong-yuan,WANG Pei,WANG Zhao-wei. Intervention effects of 2-BFI on iNOS and COX-2 mRNA In the cerebrum of mice with experimental autoimmune encephalomyelitis[J]. Chinese Journal of Neuroimmunology and Neurology, 2011, 18(1): 27-31. DOI: 10.3969/j.issn.1006-2963.2011.01.008 |
| |
| Authors: | LIN Fu-hong ZHENG Rong-yuan WANG Pei WANG Zhao-wei |
| |
| Affiliation: | LIN Fu-hong,ZHENG Rong-yuan,WANG Pei,WANG Zhao-wei.Department of Neurology,The First Affiliated Hospital of Wenzhou Medical College,Wenzhou Zhejiang 325000,China |
| |
| Abstract: | Objective To investigate the effect of 2-(2-benzofuranyl)-2-imidazoline(2-BFI),which selectively binds to imidazoline 2 receptor(I2R) with high affinity,on experimental autoimmune encephalomyelitis(EAE) mice and the underlying mechanism.Methods Female C57BL/6 mice were randomly divided into three groups:complete freund's adjuvant(CFA) control group,EAE group and 2-BFI treatment group.EAE was induced with myelin oligodendroglia glycoprotein(MOG 35-55).The behavioral changes and the daily clinical scores were... |
| |
| Keywords: | 2-BFI |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
