| 精神发育迟滞相关基因CDKL3对神经元树突棘形态发育的影响 |
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| 引用本文： | 刘赞华,赵永波. 精神发育迟滞相关基因CDKL3对神经元树突棘形态发育的影响[J]. 中国神经免疫学和神经病学杂志, 2011, 18(2): 110-113,118. DOI: 10.3969/j.issn.1006-2963.2011.02.011 |
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| 作者姓名： | 刘赞华 赵永波 |
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| 作者单位： | 1. 大连市中心医院神经内科,116003
2. 上海交通大学附属第一人民医院神经内科,200080 |
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| 摘 要： | 目的 探讨精神发育迟滞相关基因CDKL3在神经元树突棘生长形成中的作用,以及CDKL3失活与精神发育迟滞间的内在联系.方法 采用反转录实时定量聚合酶链反应(RT-realtime Quantitive PCR)方法检测内源性CDKL3基因在小鼠中枢神经系统发育中 mRNA水平的时空表达,采用RNA干扰技术和免疫荧光组化...
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| 关 键 词： | 精神发育迟滞 CDKL3 神经元 树突棘 |
The role of non-syndromic mild mental retardation candidate gene CDKL3 in the development of neuronal dendrites spine |
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| LIU Zan-hua,ZHAO Yong-bo. The role of non-syndromic mild mental retardation candidate gene CDKL3 in the development of neuronal dendrites spine[J]. Chinese Journal of Neuroimmunology and Neurology, 2011, 18(2): 110-113,118. DOI: 10.3969/j.issn.1006-2963.2011.02.011 |
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| Authors: | LIU Zan-hua ZHAO Yong-bo |
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| Affiliation: | LIU Zan-hua,ZHAO Yong-bo.Department of Neurology,The First Pepole Hospital Affiliated to Shanghai Jiaotong University,Shanghai 200080,China |
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| Abstract: | Objective To investigate the role of CDKL3 in the development of neuronal spines and further reveal the underlying relationship between CDKL3 inactivation and the non-syndromic mild mental retardation(MR).Methods The distribution and expression of Cdkl3 mRNA in developing nervous system in mouse were investigated by method of RT-Quantitive PCR.The role of CDKL3 in the development of neuronal spines in vivo were studied by the method of RNA interference and immunofluorescence.Results RT-PCR result showed tha... |
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| Keywords: | CDKL3 |
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