| 小牛血清去蛋白注射液对2型糖尿病胰岛素抵抗大鼠模型骨骼肌GLUT4 mRNA表达的影响 |
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| 引用本文： | 刘馨,徐军.小牛血清去蛋白注射液对2型糖尿病胰岛素抵抗大鼠模型骨骼肌GLUT4 mRNA表达的影响[J].中国生化药物杂志,2011,32(2). |
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| 作者姓名： | 刘馨 徐军 |
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| 作者单位： | 1. 辽宁医学院附属第一医院,辽宁,锦州,121001;辽宁中医药大学,辽宁,沈阳,110033
2. 辽宁医学院附属第一医院,辽宁,锦州,121001 |
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| 基金项目： | 辽宁省教育厅2009年度高等学校科研项目 |
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| 摘 要： | 目的观察小牛血清去蛋白注射液(DECB)对2型糖尿病胰岛素抵抗模型大鼠骨骼肌中葡萄糖转运因子4(GLUT4)的mRNA表达的影响。方法以高脂高糖饮食加链脲佐菌素制作2型糖尿病胰岛素抵抗大鼠模型,观察DECB对大鼠葡萄糖耐量(OGTT),运用RT-PCR方法检测大鼠模型骨骼肌中GLUT-4的mRNA表达。结果 DECB可改善OGTT,增加大鼠模型骨骼肌中GLUT4的mRNA表达。结论 DECB具有较好的降血糖、改善胰岛素抵抗、防治糖尿病并发症的作用。
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| 关 键 词： | 小牛血清去蛋白注射液 2型糖尿病 胰岛素抵抗 葡萄糖转运因子4 mRNA表达 |
Effects of deproteinized extract of calf blood on the expression of GLUT4 mRNA in the skeletal muscle of type 2 insulin resistance diabetic rats |
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| LIU Xin,XU Jun.Effects of deproteinized extract of calf blood on the expression of GLUT4 mRNA in the skeletal muscle of type 2 insulin resistance diabetic rats[J].Chinese Journal of Biochemical Pharmaceutics,2011,32(2). |
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| Authors: | LIU Xin XU Jun |
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| Abstract: | Purpose To observe the effects of deproteinized extract of calf blood(DECB) on the expression of GLUT4 mRNA in the skeletal muscle of type 2 insulin resistance diabetic rats.Methods The model of type 2 diabetes was established by feeding high sucrose-fat diet and injecting small dose of streptozotocin into abdomen.Then the oral glucose tolerance test(OGTT) was observed.The expression of GLUT4 mRNA in the skeletal muscle of the rats was examined by the method of RT-PCR.Results DECB could improve OGTT,increase the expression of GLUT4 mRNA in the skeletal muscle of the rats.Conclusion DECB could decrease blood glucose,improve insulin resistance,and prevent and treat the complications of diabetes effectively. |
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| Keywords: | deproteinized extract of calf blood type 2 diabetes GLUT4 mRNA expression |
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