| 生命早期抗生素暴露与儿童肥胖相关性研究进展 |
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| 引用本文： | 王雅倩,颜崇淮. 生命早期抗生素暴露与儿童肥胖相关性研究进展[J]. 中华实用儿科临床杂志, 2020, 0(1): 78-80 |
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| 作者姓名： | 王雅倩 颜崇淮 |
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| 作者单位： | 上海交通大学医学院公共卫生学院;上海交通大学医学院附属新华医院教育部和上海市环境卫生与儿童健康重点实验室 |
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| 基金项目： | 国家重点研发计划项目(2017YFC1600500)。 |
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| 摘 要： | 儿童肥胖问题是当今世界最常见的公共卫生问题之一,严重影响儿童健康。近年来儿童普遍暴露于低剂量抗生素中,抗生素问题引起国际关注。国内外研究表明儿童生命早期抗生素暴露与儿童时期肥胖风险有关,但其具体机制尚未完全明确,主要可能与抗生素导致婴幼儿肠道正常菌群定植变化,破坏早期肠道微生物群,从而增加儿童肥胖的风险,但需要进一步的研究来确认该因果机制。
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| 关 键 词： | 生命早期 抗生素暴露 儿童 肥胖 肠道菌群 |
Research progress on correlation between antibiotic exposure in early life and childhood obesity |
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| Wang Yaqian,Yan Chonghuai. Research progress on correlation between antibiotic exposure in early life and childhood obesity[J]. Chinese Journal of Applied Clinical Pediatrics, 2020, 0(1): 78-80 |
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| Authors: | Wang Yaqian Yan Chonghuai |
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| Affiliation: | (School of Public Health,Shanghai Jiao Tong University School of Medicine,Shanghai 200025,China;Ministry of Education-Shanghai Key Laboratory of Children′s Environmental Health,Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine,Shanghai 200092,China) |
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| Abstract: | Childhood obesity continues to be a public health concern worldwide,which seriously affects children′s health.In recent years,children have been generally exposed to low doses of antibiotics,and antibiotic problem has drawn international attention.Domestic and foreign researches show that antibiotic exposure in the early life of children is associated with childhood obesity risk,while its specific mechanism has not been completely clear.It is possible that antibiotics may lead to changes in the normal intestinal flora colonization of infants and young children and damage the early intestinal microflora,thus increasing the risk of childhood obesity,but further research is needed to confirm this causal mechanism. |
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| Keywords: | Early life Antibiotic exposure Child Obesity Intestinal flora |
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