| 姜黄素对人肝癌细胞株HepG-2生长及超微结构的影响 |
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| 引用本文： | 王威,贺红光,范丽,朱晓明,官阳.姜黄素对人肝癌细胞株HepG-2生长及超微结构的影响[J].华中科技大学学报(医学版),2005,34(3):323-325. |
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| 作者姓名： | 王威 贺红光 范丽 朱晓明 官阳 |
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| 作者单位： | 1. 华中科技大学同济医学院2000级七年制,武汉,430030
2. 华中科技大学同济医学院基础医学院病理学系超微病理研究室,武汉,430030 |
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| 摘 要： | 目的 探讨姜黄素对人肝癌细胞HepG-2生长抑制作用及其对细胞超微结构的影响。方法 采用MTT法观察药物对癌细胞生长的影响，应用透射电镜观察癌细胞的超微结构改变。结果 MTT法显示，姜黄素能抑制肝癌细胞的生长，随着剂量增加，其效应也增加。电镜观察显示癌细胞经姜黄素作用后超微结构发生改变，凋亡细胞多见。结论 姜黄素具有抑制HepG2肝癌细胞生长的作用，其作用机制之一为诱导细胞凋亡。
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| 关 键 词： | 姜黄素 肝癌细胞 细胞凋亡 |
| 修稿时间： | 2004年9月22日 |
Effect of Curcumin on Growth and Ultrastructure of Human Hepatocarcinoma Cell Line HepG-2 |
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| Wang Wei,He Hongguang,Fan Li et al Grade ,Tongji Medical College,Huazhong University of Science and Technology,Wuhan.Effect of Curcumin on Growth and Ultrastructure of Human Hepatocarcinoma Cell Line HepG-2[J].Journal of Huazhong University of Science and Technology(Health Sciences),2005,34(3):323-325. |
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| Authors: | Wang Wei He Hongguang Fan Li Grade Tongji Medical College Huazhong University of Science and Technology Wuhan |
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| Institution: | Wang Wei,He Hongguang,Fan Li et al Grade 2000,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030 |
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| Abstract: | Objective To investigate the effect of Curcumin on inhibiting growth and the ultrastructure of human hepatocarcinoma cell line HepG-2 in vitro.Methods The effect of Curcumin on the growth rate of tumor cells was determined by MTT method. The changes of cell ultrastructures were observed under transmission electron microscopy (TEM).Results MTT method revealed that Curcumin could inhibit the growth of the hepatocarcinoma cells in a dose-dependent manner. Under TEM, after the cells were treated with Curcumin, the ultrastructures changed and more apoptotic cells were seen.Conclusion Curcumin can inhibit the growth of hepatocarcinoma cell line HepG-2 by induction of apoptosis. |
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| Keywords: | Curcumin hepatocarcinoma cell apoptosis |
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