口服与灌肠联合口服给药治疗溃疡性结肠炎临床对比研究

目的研究口服与灌肠联合口服给药治疗溃疡性结肠炎的临床效果，为临床该类疾病的治疗提供依据。方法将59例溃疡性结肠炎患者随机分为口服给药组（对照组，口服美沙拉嗪）和口服联合灌肠给药组（治疗组，口服美沙拉嗪＋中药灌肠），比较两组患者的临床有效率，治疗前后的临床症状和肠黏膜的病变程度，并比较两组患者的不良反应。结果治疗组患者的-临床有效率可达93．8％，高于对照组，差异有统计学意义（P〈0．05）；治疗组患者临床症状积分低于对照组，差异有统计学意义（P〈0．05）；治疗组患者的肠黏膜病变程度得到明显改善，差异有统计学意义（P〈0．05）；两组不良反应发生率相似，差异无统计学意义（P〉0．05）。结论口服联合灌肠给药改善溃疡性结肠炎患者临床症状更明显，患者肠黏膜病变程度恢复更彻底，明显好于单独的口服给药，并且用药安全，无额外不良反应发生。

Clinical study on efficacy of oral administration of drugs and Chinese traditional medicine enema in treatment of 59 patients with ulcera- tive colitis

Objective To study the clinical efficacy of oral drugs combined with Chinese traditional medicine enema in treatment of ulcer- ative colitis and to provide the basis for treatment of this disease. Methods A total of 59 patients with ulcerative colitis during October 2007 to September 2011 were randomly divided into two groups, oral drug treatment group （ control group） and oral drug combined with enema group （ trial group）, patients in control group were treated with oral drugs and patients in trial group were given with oral drugs combined with Chinese medi- cine enema. Their clinical effects had been observed and compared. Results The total effective rate of trial group was 93.8% , and it was higher than that of control group, and their difference was statistically significant （ P 〈 0.05 ）. The grade of scores in elinical symptoms was the lowest for trial group, it was statistically significant compared with that of control group（ P 〈0.05） ; and the changes in lesions of intestinal mueosa in pa- tients of trial group were less than those of control group, and their difference was statistically significant （ P 〈 0.05 ） ; and the occurrence of side effects in these two groups was equivalent, and their difference was not significant （ P 〉 0.05 ）. Conclusion The effieacy of oral drugs combined with Chinese traditional medicine enema is more satisfactory in treatment of ulcerative colitis, and it is better than administration of oral drugs a- lone, there was no more side effects occurred.