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Synthesis,characterization, and anti-rheumatic potential of phthalazine-1,4-dione and its Cu(II) and Zn(II) complexes |
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| Authors: | Yousery E. Sherif Nasser M. Hosny |
| Affiliation: | 1. Chemistry Department, Faculty of Science and Arts, Ulla, Taibah University, Medina, Kingdom of Saudi Arabia 2. Clinical Pharmacology Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt 3. Chemistry Department, Faculty of Science, Port Said University, Port Said, Egypt |
| Abstract: | Two new metal complexes derived from the reaction of 2-[(2-hydroxybenzoyl) 2,3,4a,5,10,10a-hexahydro-5,10[1′,2′]-benzenobenzo[g]phthalazine-1,4-dione] (HBPD) with Cu(II) and Zn(II) have been synthesized and characterized by using elemental analysis, spectral analysis (UV–Vis, IR, 1H NMR, 13C NMR), conductance, thermal analysis, and magnetic moments. The in vivo collagen-adjuvant arthritis model in rats revealed a significant antioxidant, analgesic, and anti-rheumatic effects for HBPD and its copper and zinc complexes in comparison with standard piroxicam. The results showed that, the investigated Cu and Zn complexes have higher anti-inflammatory activity than the free ligand. |
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