| 阿司匹林对大鼠局灶性脑缺血的保护作用及其机制 |
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| 引用本文： | 林春,郑淑秋,陈崇宏,颜光美. 阿司匹林对大鼠局灶性脑缺血的保护作用及其机制[J]. 中国药理学通报, 1999, 15(5): 418-421 |
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| 作者姓名： | 林春 郑淑秋 陈崇宏 颜光美 |
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| 作者单位： | 福建医科大学生理学教研室!福州350004(林春)，中山医科大学药理学教研室!广州510080(郑淑秋，颜光美)，福建医科大学药理学教研室!福州350004(陈崇宏) |
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| 基金项目： | 国家杰出青年基金，美国中华医学基金会基金 |
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| 摘 要： | 目的 探讨阿司匹林对大鼠局灶性脑缺血的保护作用及其机制。方法 利用大鼠大脑中动脉梗塞的模型，观察阿司匹林对缺血大鼠的行为障碍，脑梗塞面积，细胞凋亡峰，细胞内钙及血浆Ｃ反应蛋白的影响。结果 阿司匹林能明显改善行为障碍，显著降低缺血大鼠的脑梗塞面积，降低细胞凋亡峰，细胞内钙水平和血浆Ｃ反应蛋白。结论 阿司匹林对大鼠局灶性脑缺血具有保护作用，而且其作用机制与抗凋亡，降低细胞内钙及血浆Ｃ反应蛋白有关
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| 关 键 词： | 大鼠 大脑中动脉梗塞 缺血性脑卒中 C反应蛋白 细胞内钙 细胞凋亡 |
The protective effects of aspirin on local cerebral ischemia in rats and its mechanism of action |
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| LIN Chun ,ZHENG Shu Qiu,CHEN Choug Hong ,YAN Guang Mei. The protective effects of aspirin on local cerebral ischemia in rats and its mechanism of action[J]. Chinese Pharmacological Bulletin, 1999, 15(5): 418-421 |
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| Authors: | LIN Chun ZHENG Shu Qiu CHEN Choug Hong YAN Guang Mei |
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| Affiliation: | LIN Chun 1,ZHENG Shu Qiu,CHEN Choug Hong 2,YAN Guang Mei |
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| Abstract: | AIM To investigate the protective effects of aspirin on local cerebral ischemia in rats and its mechanism of action. METHODS To observe effects of aspirin on neurological deficits, the infarct area of brain, peak of cell apoptosis, intracellular calcium([Ca 2 ] i) and C reactive protein (CRP)of plasma by the model of the right middle cerebral artery occlusion in rats. RESULTS All of neurological deficits, the infarct area of brain, peak of cell apoptosis, [Ca 2 ] i and CRP can be decreased by aspirin. CONCLUSION Aspirin has protective effects on local cerebral ischemia in rats, and its mechanism is related to anti apoptosis and lowering of [Ca 2 ] i and CRP. |
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| Keywords: | rat middle cerebral artery occlusion ischemic stroke C reactive protein intracellular calcium cell apoptosis |
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