| 利福定在家犬体内的药物动力学 |
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| 引用本文： | 何仲贵,蔡玉珉. 利福定在家犬体内的药物动力学[J]. 沈阳药科大学学报, 1990, 0(1) |
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| 作者姓名： | 何仲贵 蔡玉珉 |
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| 作者单位： | 沈阳药学院生物药剂研究室(何仲贵)，沈阳药学院生物药剂研究室(蔡玉珉) |
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| 摘 要： | 本文用反相高效液相色谱方法测定体液中利福定的含量。比较了健康家犬与胆瘘术后家犬的药物动力学参数的差异。家犬口服150mg利福定,胆汁平均排泄量为11.8mg。实验表明肠肝循环对药物动力学参数有很大影响。
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| 关 键 词： | 利福定 高效液相色谱 药物动力学 肠肝循环 |
PHARMACOKINETICS OF RIFANDIN IN DOGS |
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| He Zhonggui,Cai Yumin,Research. PHARMACOKINETICS OF RIFANDIN IN DOGS[J]. Journal of Shenyang Pharmaceutical University, 1990, 0(1) |
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| Authors: | He Zhonggui Cai Yumin Research |
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| Affiliation: | He Zhonggui,Cai Yumin,Research Department of Biopharmacy |
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| Abstract: | Reversed phase HPLC method was used for the determination of rifandin inbiological fluids. Difference of pharmacokinetic parameters between healthy dogs andthe dogs with biliary fistulae was found to exist. After oral administration of 150mgof rifandin, biliary excretion was found to be 11.8 mg. It was shown that entero-hepatic circulation played an important role in deciding pharmacokinetic parameters. |
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| Keywords: | Rifandin HPLC Pharmacokinetics Enterohepatic circulation |
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