维尼安治疗萎缩性鼻炎的动物实验研究

目的　比较滴鼻和胃灌注维尼安治疗萎缩性鼻炎的疗效及二者的差异。方法　双侧卵巢切除制备萎缩性鼻炎动物模型。 60只萎缩性鼻炎动物随机分成 2组 ,每组 3 0只 ,分别予以维尼安滴鼻和胃灌注治疗。每只动物于术前 15d、术后 15 d及处死前分别抽血检测血清雌二醇 ( E2 )与促黄体生成素 ( FSH)。治疗后 3 0、 45、 60 d分批处死 ,取鼻中隔粘膜行形态学观察。结果　双侧卵巢切除术后 3 0 d,鼻粘膜呈萎缩性改变。维尼安滴鼻和胃灌注治疗后 ,萎缩的鼻粘膜恢复正常。滴鼻组 E2 和 FSH水平无明显改变。胃灌注组 E2 和 FSH水平发生明显改变 ,与术前、治疗前比较 ,差异都有显著性 (均为 P<0 .0 5 )。结论　维尼安在治疗萎缩性鼻炎方面有疗效 ,滴鼻法比口服法简单 ,并能避免雌激素的副作用 ,更具有临床应用价值

Experimental Study on the Treatment of Atrophic Rhinitis by Weinian in Ovariectomized Rats

Objective To compare the therapeutic effectiveness of Weinian by nasal drip or gastrogavage in the treatment of atrophic rhinitis in ovariectomized rats. Methods Rat atrophic rhinitis models were made by ovariectomy. Sixty rats with atrophic rhinitis were divided into two groups at random (30 rats in each group). One group was treated by Weinian via nasal drip and the other treated by gastrogavage. Serum estrodiol (E 2) and FSH in the rats was determined by radioimmunoassay at 15th day before operation, 15th day after operation and immediate after killing. Morphological changes of the nasal mucosas were observed under light-microscopy after treating for 30 days, 45 days and 60 days in two groups. Results Atrophic rhinitis occured 30 days after ovariectomy. After treatment with Weilian via nasal drip or gastrogavage, the atrophic nasal mucosa recovered. In the gastrogavage group, E 2 and FSH obviously changed after operation (P<0.05), but E 2 and FSH had no change in the nasal drip group (P>0.05). After Weilian gastrogavage, E 2 and FSH changed significantly as compared with those before operation and those before treatment (P<0.05). Conclusion Weinian has effects in the treatment of atrophic rhinitis. Weilian by nasal drip was more convenient than by gastrogavage. Nasal drip could avoid by-effect of estrogen and would be more likely to be used in clinical practice.