天花粉对妊娠大鼠子宫中孕酮、孕酮受体和前列腺素含量的影响

天花粉对大鼠有抗早孕作用,使妊娠大鼠血浆孕酮浓度,子宫中孕酮和孕酮受体的含量下降,子宫中的PGF_2α含量增高,同时增敏子宫对15-Me-PGR_2α和催产素的反应性,消炎痛能抑制离体妊娠子宫自发收缩活动,但并不抑制天花粉增敏子宫对15-Me-PGF_2α和催产素反应性的作用,实验结果提示天花粉促进子宫PGF_2α的含量增加和增敏子宫对催产物质的反应性是它增加妊娠子宫自发收缩活动的重要机制,而天花粉的上述作用又可能与它使子宫中孕酮和孕酮受体下降有关。

Effect of trichosanthin on progesterone, progesterone receptor and prostaglandin F2 alpha levels in pregnant rat uteri

Trichosanthin given im to pregnant rats decreased the plasma progesterone concentration and the level of progesterone and cytosol progesterone receptor in uteri and increased the content of uterine PGF_2α. When the dose response in smooth muscle of pregnant rat uteri was studied after im injection of trichosanthin, the response to 15-Me-PGF_2α and oxytocin was enhanced significantly.Based upon the above experiments it is suggested that: (1) As a result of the deleterious action of trichosanthin on placenta, the PGF_2α content of the uteine tissue was increased. (2) The increase of uterine content of PGF_2α and response to 15-Me-PGF_2α and oxytocin are related to the decrease of plasma progesterone concentration and the level of uterine progesterone and cytosol progesterone receptor.