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Polymorphisms in TGFB1 and PDGFRB are associated with Moyamoya disease in European patients |
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| Authors: | Constantin Roder Vera Peters Hidetoshi Kasuya Tsutomu Nishizawa Yayoi Takehara Daniela Berg Claudia Schulte Nadia Khan Marcos Tatagiba Boris Krischek |
| Affiliation: | 1. Department of Neurosurgery, University of Tübingen, Hoppe-Seyler-Str.3, 72076, Tübingen, Germany 2. Division of Neurosurgery, Medical Center East, Tokyo Women’s Medical University, Tokyo, Japan 3. International Research and Educational Institute for Integrated Medical Sciences, Tokyo Women’s Medical University, Tokyo, Japan 4. Department of Neurodegeneration, Hertie-Institute of Clinical Brain Research and German Center for Neurodegenerative Diseases (DZNE), University of Tübingen, Tübingen, Germany 5. Department of Neurosurgery and Stanford Stroke Center, Stanford University School of Medicine, Stanford, CA, USA |
| Abstract: | BackgroundThe etiology of Moyamoya disease (MMD) is still widely unknown. Several publications on Moyamoya describe differences of cytokine and growth factor concentrations in different specimen. We analyzed the DNA of patients with MMD for single nucleotide polymorphisms (SNPs) in and upstream of the genes for previously described associated cytokines and growth factors. |
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