Cholinergic enzymatic activity of cerebrospinal fluid of patients with various neurologic diseases |
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| Authors: | S Johnson E F Domino |
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| Affiliation: | Department of Pharmacology, University of Michigan, Ann Arbor and Lafayette Clinic, Detroit, MichiganU.S.A. |
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| Abstract: | The cerebrospinal fluid (CSF) of normal humans contains both true and pseudocholinesterases and choline acetyl transferase (choline acetylase) detectable by radiochemical assay. Elevations of total cholinesterase, pseudocholinesterase, and true cholinesterase occur in brain tumors, meningitis, Guillain-Barre disease, hydrocephalus, and brain abscess. However, the non-specificity and inconstancy of CSF cholinesterase changes in neurologic diseases limit its clinical usefulness. |
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