不同方案硝酸咪康唑栓治疗VVC再发的疗效比较

目的评价硝酸咪康唑1200mg强化治疗及巩固不同疗程治疗外阴阴道念珠菌病（VVC）再发的效果，探讨再发VVC的优化治疗方案。方法采取开放、非对照性临床试验。试验分三组，A组强化治疗，B组在此基础上巩固1个月，C组巩固2个月。对不同疗程患者周药前、用药后7～14d、用药后每个月进行妇科检查、临床症状体征评分、真菌学检查，评估疗效至停药2个月。结果70例患者入选，6例失访，停药2个月时共64例可评价人群。硝酸咪康唑1200mg强化治疗和巩固1-2个疗程的临床治愈率分别为52．4％、52．6％、54．2％；临床总有效率分别为85．7％、94．7％、91．7％；真菌学疗效分别为90．5％、94．7％、95．8％；三组间无统计学差异。结论VVC再发强化治疗效果满意，与巩固1．2疗程治疗疗效相当，增加1．2个疗程不能提高远期疗效和降低复发率。

Comparison of effects of miconazolenitrate suppository on recurrent vulvovaginal candidiasis

Objective To evaluate the effects of 1200mg miconazole nitrate intensive treatment and consolidation treatment on recurrent vulvovaginal eandidiasis. Methods An open,non-controlled clinical trial was conducted by allocating the subjects into three groups： group A,intensive treatment; group B, consolidation treatment for one more month than group A; group C, consolidation treatment for two nore than group A. The gynecological examination,clinical signs and symptoms score and mycological examination were conducted monthly. Results A total of 70 patients were enrolled in the trial, among which five lost follow-up and three dropped out in advance during follow-up observation due to being positive in the mycological examination. Sixty-two cases were evaluable two months after drug withdrawal. The clinical cure rates of patients using 1 200 mg mieonazole nitrate intensive treatment and 1-2 courses of consolidation were respectively 55%, 52.6% and 56.5%; the total clinical effective rates were 90% ,94.7% and 95.7%; mycological clearance rates were 90.9%, 94.7% and 95.8%; without showing statistical difference among the three groups. Conclusion The efficacy of intensive treatment on reeurrent vulvovaginal candidiasis is satisfactory.