盐酸替罗非班对急性ST段抬高型心肌梗死患者急诊冠状动脉介入术心肌灌注的影响

目的:探讨盐酸替罗非班对急性ST段抬高型心肌梗死(STEMI)患者行急诊冠状动脉介入术(PCI)后心肌组织的再灌注影响。方法:符合STEMI入选标准的患者69例,随机分为治疗组(32例)和对照组(37例)。治疗组术前常规给予低分子肝素、阿司匹林、氯吡格雷、调脂药等治疗,术中加用盐酸替罗非班以输液泵持续泵入;对照组除未加盐酸替罗非班外,其他治疗同治疗组。2组术中都常规应用普通肝素。联合应用TMP(TIMI myocardial perfusion)和sumSTR(sum-ST-segment resolution)方法对心肌组织的灌注进行评价。结果:2种评价方法均显示治疗组急诊PCI后心肌组织的再灌注优于对照组(均P<0.05)。结论:盐酸替罗非班能明显改善STEMI患者急诊PCI后心肌组织的再灌注水平。

Effects of tirofiban on myocardial reperfusion after primary percutaneous coronary intervention in patients with ST elevation acute myocardial infarction

Objective:To study the situation of myocardial reperfusion after primary percutaneous coronary intervention(PCI) in patients with ST segment elevation acute myocardial infarction (STEMI) who were treated with tirofiban. Method:There were 69 patients diagnosed STEMI in the study. They were randomly divided into 2 groups: treatment group (n=37) and control group (n=32). Both of them were given low molecular weight heparin, aspirin, clopidogrel and antilipidemic agents before PCI, Heparin were given during and after PCI, the treatment group was treated with tirfiban during and after the operation. The myocardial reperfusion was assessed by TIMI myocardial perfusion and sum-ST-segment resolution. Result:Both assessing methods showed that the myocardial reperfution of treatment group was better than that of control group (P<0.05). Conclusion:Tirofiban can improve the situation of myocardial reperfusion after PCI in patients with STEMI.