缺血性卒中患者血尿酸水平与颈动脉狭窄的关系

目的 研究缺血性卒中患者血尿酸（serum uric acid，SUA）与颈动脉狭窄之间的关系。方法 经脑血管造影术确诊有颈动脉狭窄的缺血性卒中患者112例，无狭窄者50例。根据造影结果，将颈动脉狭窄分轻度狭窄组45例、中度狭窄组39例和重度狭窄组28例。单侧颈动脉狭窄有62例，双侧颈动脉狭窄有50例。比较不同组别间SUA水平的差异以及SUA与颈动脉狭窄程度之间的关系。结果 颈动脉狭窄组SUA水平显著高于无狭窄组（343±111μmol/L vs 287±67μmol/L，P<0.01）；重度狭窄组SUA水平高于中度狭窄组和轻度狭窄组（408±112μmol/L vs 351±100μmol/L，P=0.025；408±112μmol/L vs 296±99μmol/L，P<0.01）；中度狭窄组SUA水平高于轻度狭窄组（P=0.017）；双侧颈动脉狭窄组SUA水平高于单侧狭窄组（378±128μmol/L vs 314±85μmol/L，P=0.003）。Logistic回归分析提示，SUA并非颈动脉狭窄与否的独立危险因素（P=0.239）；Spearman等级相关分析提示，SUA水平与颈动脉狭窄程度呈正相关（r=0.401，P<0.01）。结论 高血尿酸是颈动脉狭窄与否的重要但非独立危险因素，与颈动脉狭窄严重程度呈正相关。

The Relationship Between Serum Uric Acid and Carotid Stenosis in Patients with Ischemic Stroke

Objective To study the relationship between serum uric acid（SUA） level and carotid stenosis in patients with ischemic stroke.
Methods Patients with ischemic stroke were examined with subtraction and diagnosed as with（112） and without carotid stenosis（50）. Patients with stenosis were further grouped as slight（45）, moderate（39） and severe stenosis（28）. There were 62 patients with unilateral and 50 patients with bilateral carotid stenosis.
Results The level of SUA was significantly higher in patients with carotid stenosis（343±111μmol/L） than in patients without（287±67μmol/L）（P〈0.01）. SUA was significantly higher in patients with severe stenosis（408±112μmol/L） than in patients with moderate stenosis（351±100μmol/L）（P=0.025） and mild stenosis（296±99μmol/L）（P〈0.01）, significantly higher in patients with moderate stenosis than in patients with mild stenosis（P=0.017）, significantly higher in patients with bilateral stenosis group（378±128μmol/L） than in unilateral stenosis（314±85μmol/L）（P=0.003）. Logistic regression analysis showed that SUA level was not an independent risk factor of carotid stenosis（P=0.239）. Spearman rank correlation analysis showed that SUA level and the degree of carotid stenosis was positively correlated（r=0.401, P〈0.01）.
Conclusion SUA level may be an important but not independent risk factor for carotid stenosis. There was a correlation between SUA level and the severity of the carotid stenosis.