聚合物胶束口服吸收机制的研究进展

目的对聚合物胶束作为口服给药载体的研究方法和吸收机制进行综述。方法参考近年来国内外文献共19篇,总结有关聚合物胶束作为口服给药载体的研究,对其中涉及到的口服吸收机制做以分类和总结。结果目前在聚合物的口服吸收常用的研究方法有Caco-2细胞模型、小肠翻转模型和动物模型,共同作为研究聚合物口服吸收机制的手段。聚合物胶束作为药物载体口服的吸收机制分为:a.通过抑制P-糖蛋白增加吸收;b.以胞饮形式吸收;c.经被动扩散;d.与胆汗相关的吸收。结论对聚合物胶束作为口服给药载体的研究方法和吸收机制进行了报道,为聚合物口服研究提供了参考。

Advances on the oral absorption of polymeric micelles

Objective To summarize the methods and mechanisms involved in researches about oral polymeric micelles. Methods According to the polymeric micelles with regard to carrier of oral uptake, the oral absorption of polymeric micelles were classified and reviewed on the basis of published literatures. Results Caco-2 cells, everted rat intestine, and animal model can be used as common models to investigate the absorption mechanism for oral polymeric micelles. With these models, four mechanisms had been introduced to explain the phenomenon related to micelles absorption, i. e. inhibition P-gp, pinocytosis, simple passive diffusion and the oral uptake with the influence of the bile. Conclusions The methods and mechanisms involved in researches about oral polymeric micelles are reviewed, and this article will provide references for the studies of polymeric micelles for oral administration.