“Radiation Hormesis”中的剂量率效应 |
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引用本文: | 苏旭,刘树铮,相泽志郎,大山ハルシ,山田武. “Radiation Hormesis”中的剂量率效应[J]. 吉林大学学报(医学版), 1997, 0(6) |
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作者姓名: | 苏旭 刘树铮 相泽志郎 大山ハルシ 山田武 |
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作者单位: | 卫生部放射生物重点实验室,日本国立放射医学研究所,日本东邦大学生物学研究室 |
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摘 要: | 为了揭示不同剂量率X射线低剂量全身照射对低剂量辐射兴奋效应(RadiationHormesis)的影响,采用不同剂量率(12.7mGy/min和0.2Gy/min)对Balb/c小鼠进行低剂量全身照射,研究了低剂量辐射兴奋效应中的剂量率效应。结果表明:采用不同剂量率X射线照射同一剂量时,所引起的生物效应不同。剂量率为12.7mGy/min时,脾细胞3H-TdR参入量对ConA的反应性明显增强,尤其以76.7mGy和105.5mGy照射组最为显著(P<0.01),表现出明显的辐射免疫兴奋效应。而剂量率为0.2Gy/min时,在105.5mGy以内,脾细胞3H-TdR参入量对ConA的反应性无明显变化。该结果提示:高剂量率低剂量全身照射不能引起低剂量辐射兴奋效应。
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关 键 词: | 剂量率效应 低剂量辐射 免疫兴奋效应 |
Influence of dose rate on radiation hormesis with low dose exposure |
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Abstract: | In order to explore the influence of dose rate on radiation hormesis after low dose irradiation,Balb/c mice were irradiated at a same total dose with dose rates of 12.7 mGy/min and 0.2 Gy/min.The results showed that different biological effects were induced by different dose rates at the same dose .The response of splenic lymphocytes to Con A assessed by 3H-TdR incorporation was increased after irradiation with a dose rate of 12.7 mGy/min,which is especially marked following total doses of 76.7 mGy and 105.5 mGy ( P <0 01).However,the response of splenic lymphocytes to Con A showed no significant changes after irradiation with a dose rate of 0.2 mGy/min at the same total dose.The result indicated that low dose radiation hormesis could not be induced by high dose rate X-rays. |
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Keywords: | Dose rate Low dose radiation Immunoenhancement |
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