Human alpha-L-fucosidases

Two forms of α-l-fucosidase from various human organs, designated by us as α-l-fucosidase I and α-l-fucosidase II, were separated by means of gel filtration on Sephadex G-200.The pH optimum for α-l-fucosidase I and α-lα-l-fucosidase II was found to be 4.5–5.0 and 5.5, respectively. Both forms differed in thermostability, pH-stability and possess strict substrate specificities.The data on the presence of fucosidases in human amniotic fluid and placenta are of interest since these organs could be used as sources for study of these enzymes in certain hereditary diseases.