| 茯苓抗肿瘤成分研究(Ⅰ) |
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| 引用本文： | 赵吉福,何爱民,陈英杰,姚新生,裴玉萍.茯苓抗肿瘤成分研究(Ⅰ)[J].中国药物化学杂志,1993(2). |
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| 作者姓名： | 赵吉福 何爱民 陈英杰 姚新生 裴玉萍 |
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| 作者单位： | 沈阳药学院植物化学教研室，沈阳药学院中药系，沈阳药学院植物化学教研室，沈阳药学院植物化学教研室，沈阳药学院植物化学教研室 沈阳 110015，55期专题生，沈阳 110015，沈阳 110015，沈阳 110015 |
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| 基金项目： | 国家中医药局青年科技基金 |
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| 摘 要： | 用硅胶柱层析法从茯苓Poria cocos(Schw.)Wolf的干燥菌核中分离出一种三萜类有机酸,根据理化性质及光谱数据确定为茯苓酸(Pachymic acid),抗肿瘤实验表明茯苓酸对小鼠Sarcoma 180抑制率达62.8％,茯苓中的水溶性低分子量化合物无抗肿瘤活性。
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| 关 键 词： | 茯苓 茯苓酸 抗肿瘤活性 |
THE ISOLATION AND IDENTIFICATION OF ANTITUMOR INGREDIENTS FROM THE MYCELIA OF PORIA COCOS WOLF |
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| Zhao Jifu He Aimin Chen Yingjie Yao Xinsheng Pei Yuping.THE ISOLATION AND IDENTIFICATION OF ANTITUMOR INGREDIENTS FROM THE MYCELIA OF PORIA COCOS WOLF[J].Chinese Journal of Medicinal Chemistry,1993(2). |
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| Authors: | Zhao Jifu He Aimin Chen Yingjie Yao Xinsheng Pei Yuping |
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| Abstract: | Lower molecule compounds frationated from the mycelia of Poria cocos were evaluated for antitumor activity against mouse tumor. The water-soluble fration of ethanol extract was found to be inactive against intraperitoneally implanted Sarcoma180. The chloroform-soluble fraction of ethanol extract and pachymic acid which has been isolated from Poria cocos and identified by physical properties and spectral data showed strong antitumor activity. |
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| Keywords: | Poria cocos Antitumor activity Pachymic acid |
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