57例辛伐他汀影响急性缺血性卒中的临床分析

目的评估发病前使用辛伐他汀对急性缺血性卒中发病时症状严重程度及出院时功能转归的影响。方法回顾性分析我院收治的121例急性缺血性卒中患者的临床资料，根据发病前是否使用辛伐他汀治疗分为治疗组（57例）和对照组（64例），对比两组的一般资料、血管危险因素、入院时美国国立卒中量表评分、出院时Barthel指数等。结果治疗组入院时NIHSS评分低于对照组（6．0vs13．0，P〈0．01），出院时功能转归良好病例百分比高于对照组（77．2％VS40．6％，P〈0．01）。出院时功能转归良好与发病前使用辛伐他汀相关（OR=5．784，P〈O．01）。结论发病前使用辛伐他汀能减轻急性缺血性卒中症状及改善出院时功能转归。

Clinical Analysis of the Effect of Simvastatin on Ischemic Stroke

Objective To evaluate the independent effect of premorbid simvastatin on incident ischemic stroke severity and outcome at discharge. Methods A total of 121 cases study criteria：57 patients were on simvastatin agents prior to admission and 64 were on no simvastatln. We included consecutive patients with ischemic stroke and recorded demographic data, vascular risk factors, the method of treatment National Institutes of Health Stroke Scale score, and Barthel index. Results Pretreatment with simvastatin was associated weth lower presenting median NIHSS（6.0 vs 13.0,P〈 0.01 ）. The likelihood of a good outcome was incieased in those on simvastatin after adjusting for other variables（OR=5.784,P〈 0.01 ）. Conclusion Prestroke use of simvastatin may be associated with reduced severity of incident ischemic stroke and may provide benefits for the functional outcome.