The clinical electrophysiology of intravenous indecainide |
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| Authors: | L N Horowitz S R Spielman C R Webb J Morganroth A M Greenspan |
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| Affiliation: | 1. Department of Chemistry, Kandi Raj College, Murshidabad 742137, India;2. Department of Chemistry, Chung Yuan Christian University, Chung-Li 320, Taiwan;3. Departamento de Química, CICECO, Universidade de Aveiro, 3810-193 Aveiro, Portugal;4. Departamento de Química, IBIMED and CICECO, Universidade de Aveiro, 3810-193 Aveiro, Portugal;1. Liquid Crystal Research Laboratory, School of Chemical Sciences, Universiti Sains Malaysia, 11800 Minden, Penang, Malaysia;2. Institute for Research in Molecular Medicine, Universiti Sains Malaysia, 11800, Minden, Penang, Malaysia;3. Faculty of Science & Engineering, Soka University, 1-236 Tangi-cho, Hachioji, Tokyo, 192-8577, Japan;1. School of Chemistry and Chemical Engineering, Guangxi University, Nanning 530004, China;2. Faculty of Chinese Medicine Science, Guangxi University of Chinese Medicine, Nanning 530004, China;3. Department of Chemistry, Sarhad University of Science & Information Technology, Peshawar, Khyber Pakhtunkhwa 25120, Pakistan;4. Medicinal College, Guangxi University, Nanning 530004, China;1. Institute of Inorganic Chemistry, Leibniz University Hannover, D-30167 Hannover, Germany;2. Institute of Inorganic Chemistry, FCHPT, Slovak University of Technology, SK-812 37 Bratislava, Slovakia;3. Regional Centre of Advanced Technologies and Materials, and Department of Inorganic Chemistry, Faculty of Science, Palacký University, CZ-779 00 Olomouc, Czech Republic;4. Department of Chemistry, FPV, University of SS Cyril and Methodius, SK-917 01 Trnava, Slovakia;1. Department of Chemistry, University of Kalyani, Kalyani 741235, India;2. Department of Chemistry, Kalyani Govt. Engg. College, Kalyani 741235, India;3. Department of Chemistry, East Calcutta Girls’ College, Kolkata 700089, India;4. Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal |
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| Abstract: | The electrophysiologic effects of indecainide, a new class IC antiarrhythmic agent, were assessed in 10 patients with left ventricular dysfunction and inducible sustained ventricular tachycardia. Indecainide was administered intravenously in a dose of 60 to 90 mg/kg at a rate of 12.5 to 15 micrograms/kg/min. Indecainide had no effect on sinus node function or atrial and ventricular effective refractory periods. The AH (106 +/- 13 vs 130 +/- 24 msec, p less than 0.002) and HV (57 +/- 7 vs 73 +/- 19 msec, p less than 0.001) intervals were significantly increased. The QRS duration increased (102 +/- 9 vs 120 +/- 13 msec, p less than 0.001); however, the JT duration did not change. Induction of ventricular tachycardia was prevented in 1 of 10 patients. In the remaining nine patients, the ventricular tachycardia cycle length was significantly prolonged (248 +/- 47 vs 320 +/- 71 msec, p less than 0.001). Indecainide significantly depressed intracardiac conduction at several sites. |
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