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Myofibroblast depletion reduces kidney cyst growth and fibrosis in autosomal dominant polycystic kidney disease
Affiliation:1. Department of Human Genetics, Leiden University Medical Centre, Leiden, the Netherlands;2. Division of Nephrology, University Health Network, Toronto, Ontario, Canada;3. Laboratory Medicine and Pathobiology, University Health Network, Toronto, Ontario, Canada;4. Centre for Metabolism, Obesity and Diabetes Research, McMaster University, Hamilton, Ontario, Canada;5. Division of Nephrology, University of Toronto, Toronto, Ontario, Canada;6. Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada;1. Department of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City, Kansas, USA;2. The Kidney Institute, University of Kansas Medical Center, Kansas City, Kansas, USA;3. Department of Pathology, University of Kansas Medical Center, Kansas City, Kansas, USA;4. VU University Medical Center, Amsterdam, The Netherlands;5. Department of Medicine, University of Kansas Medical Center, Kansas City, Kansas, USA
Abstract:
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  • Keywords:α-smooth muscle actin  cell proliferation  extracellular matrix  fibrosis  ganciclovir  microenvironment  PAI1  thymidine kinase  TIMP1
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