|
|||||
|
|
Humoral and cellular immune response dynamics in Japanese healthcare workers up to six months after receiving a third dose of BNT162b2 monovalent vaccine |
|
| Affiliation: | 1. Department of Laboratory Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan;2. Department of Infectious Diseases, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan;3. Department of Public Health and Preventive Medicine, Keio University School of Medicine, Japan;4. Clinical Laboratory, Keio University Hospital, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan;5. Keio University Health Center, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan;6. Center for Clinical Genetics, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan;7. Clinical Research Center for Medicine, International University of Health and Welfare, 4-1-26 Akasaka, Minato-ku, Tokyo 107-8402, Japan |
| Abstract: | Longitudinal data on the immune response from the first dose to several months after the third dose of COVID-19 vaccine are limited. We analyzed the immune response in 406 Japanese healthcare workers who received at least three doses of vaccine. The geometric mean anti-receptor binding domain IgG antibody titers and antigen-stimulated T-cell interferon-gamma levels after 6 months after receiving a third dose were similar to those 8 weeks after receiving a second dose. Humoral and cellular immunity induced by the third dose was more durable than that induced by the second dose.UMIN Clinical Trials Registry ID: UMIN000043340. |
| Keywords: | COVID-19 vaccine BNT162b2 Third dose Antibody Cellular immunity |
| 本文献已被 ScienceDirect 等数据库收录！ | |