Variables associated with in-hospital and postdischarge outcomes after postcardiotomy extracorporeal membrane oxygenation: Netherlands Heart Registration Cohort |
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| Affiliation: | 7. Department of Cardio-Thoracic Surgery, Erasmus Medical Center, Rotterdam, The Netherlands;8. Department of Cardio-Thoracic Surgery, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands;9. Department of Cardio-Thoracic Surgery, Leids University Medical Center, Leiden, The Netherlands;10. Department of Cardio-Thoracic Surgery, Amphia Hospital, Breda, The Netherlands;11. Department of Cardio-Thoracic Surgery, Sint Antonius Hospital, Nieuwegein, The Netherlands;12. Department of Cardio-Thoracic Surgery, Haga Hospital, Den Haag, The Netherlands;13. Department of Cardio-Thoracic Surgery, University Medical Center Utrecht, Utrecht, The Netherlands;14. Department of Cardio-Thoracic Surgery, Catarina Hospital, Eindhoven, The Netherlands;15. Department of Cardio-Thoracic Surgery, Radboud University Medical Center (Radboudumc), Nijmegen, The Netherlands;p. Department of Cardio-Thoracic Surgery, Isala Clinic Zwolle, Zwolle, The Netherlands;q. Department of Cardio-Thoracic Surgery, University Medical Center Groningen, Groningen, The Netherlands;r. Department of Cardio-Thoracic Surgery, Medical Center Leeuwarden, Leeuwarden, The Netherlands;s. Department of Cardio-Thoracic Surgery, Thoraxcenter Medical Spectrum Twente, Enschede, The Netherlands;t. Department of Cardio-Thoracic Surgery, OLVG, Amsterdam, The Netherlands;u. Department of Cardio-Thoracic Surgery, Amsterdam UMC-Location VUmc, Amsterdam, The Netherlands;1. Department of Cardio-Thoracic Surgery, Maastricht University Medical Centre, Maastricht, The Netherlands;2. Cardiovascular Research Institute Maastricht, Maastricht, The Netherlands;3. Department of Intensive Care Medicine, Maastricht University Medical Centre, Maastricht, The Netherlands;4. Care and Public Health Research Institute, Maastricht University, Maastricht, The Netherlands;5. Netherlands Heart Registration, Utrecht, The Netherlands;6. Department of Cardiology, Maastricht University Medical Centre, Maastricht, The Netherlands |
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| Abstract: | ObjectivesExtracorporeal membrane oxygenation (ECMO) for postcardiotomy cardiogenic shock has been increasingly used without concomitant mortality reduction. This study aims to investigate determinants of in-hospital and postdischarge mortality in patients requiring postcardiotomy ECMO in the Netherlands.MethodsThe Netherlands Heart Registration collects nationwide prospective data from cardiac surgery units. Adults receiving intraoperative or postoperative ECMO included in the register from January 2013 to December 2019 were studied. Survival status was established through the national Personal Records Database. Multivariable logistic regression analyses were used to investigate determinants of in-hospital (3 models) and 12-month postdischarge mortality (4 models). Each model was developed to target specific time points during a patient's clinical course.ResultsOverall, 406 patients (67.2% men, median age, 66.0 years [interquartile range, 55.0-72.0 years]) were included. In-hospital mortality was 51.7%, with death occurring in a median of 5 days (interquartile range, 2-14 days) after surgery. Hospital survivors (n = 196) experienced considerable rates of pulmonary infections, respiratory failure, arrhythmias, and deep sternal wound infections during a hospitalization of median 29 days (interquartile range, 17-51 days). Older age (odds ratio [OR], 1.02; 95% CI, 1.0-1.04) and preoperative higher body mass index (OR, 1.08; 95% CI, 1.02-1.14) were associated with in-hospital death. Within 12 months after discharge, 35.1% of hospital survivors (n = 63) died. Postoperative renal failure (OR, 2.3; 95% CI, 1.6-4.9), respiratory failure (OR, 3.6; 95% CI, 1.3-9.9), and re-thoracotomy (OR, 2.9; 95% CI, 1.3-6.5) were associated with 12-month postdischarge mortality.ConclusionsIn-hospital and postdischarge mortality after postcardiotomy ECMO in adults remains high in the Netherlands. ECMO support in patients with higher age and body mass index, which drive associations with higher in-hospital mortality, should be carefully considered. Further observations suggest that prevention of re-thoracotomies, renal failure, and respiratory failure are targets that may improve postdischarge outcomes. |
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| Keywords: | mechanical circulatory support extracorporeal membrane oxygenation extracorporeal life support postcardiotomy cardiogenic shock cardiac surgery acute heart failure BMI" },{" #name" :" keyword" ," $" :{" id" :" kwrd0045" }," $$" :[{" #name" :" text" ," _" :" body mass index ECMO" },{" #name" :" keyword" ," $" :{" id" :" kwrd0055" }," $$" :[{" #name" :" text" ," _" :" extracorporeal membrane oxygenation NHR" },{" #name" :" keyword" ," $" :{" id" :" kwrd0065" }," $$" :[{" #name" :" text" ," _" :" Netherlands Heart Registration |
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