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Ubiquitin-specific protease 11 promotes partial epithelial-to-mesenchymal transition by deubiquitinating the epidermal growth factor receptor during kidney fibrosis
Affiliation:1. Department of Nephrology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China;2. School of Life Science and Technology, Advanced Institute of Translational Medicine, Tongji University, Shanghai, China;3. Department of Medicine, Rhode Island Hospital and Alpert Medical School, Brown University, Providence, Rhode Island, USA;1. Renal Division, Peking University First Hospital, Beijing, China;2. Institute of Nephrology, Peking University, Beijing, China;3. Key Laboratory of Renal Disease, Ministry of Health of China, Beijing, China;4. Key Laboratory of CKD Prevention and Treatment, Ministry of Education of China, Beijing, China;5. Department of Nephrology, Tianjin Medical University General Hospital, Tianjin, China;6. Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing, China;7. Peking-Tsinghua Center for Life Sciences, Beijing, China;8. Department of Pharmacology, University of Pennsylvania, Perelman School of Medicine, Philadelphia, Pennsylvania, USA;9. Institute for Translational Medicine and Therapeutics, University of Pennsylvania, Perelman School of Medicine, Philadelphia, Pennsylvania, USA;10. Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China;11. Sorbonne Université, Paris, France;12. Institut National de la Santé et de la Recherche Médicale (Inserm), Unité Mixte de Recherche S1155, Paris, France;13. Department of Nephrology, Centre Hospitalier du Mans, Le Mans, France;1. Key Laboratory of Infection and Immunity of Shandong Province, Department of Pharmacology, School of Basic Medical Sciences, Shandong University, Jinan, China;2. Department of General Surgery, First Affiliated Hospital of Shandong First Medical University, Jinan, China;3. Department of Pathology, School of Basic Medical Sciences, Shandong University, Jinan, China;4. Department of Nephrology, First Affiliated Hospital of Zhengzhou University, Zhengzhou, China;1. Department D of Internal Medicine, University Hospital of Munster, Munster, Germany;2. Institute of Medical Physics and Biophysics, University of Munster, Munster, Germany;1. Thomas E. Starzl Transplantation Institute, Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, USA;2. Renal and Electrolyte Division, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA;3. Division of Transplantation Pathology, Thomas E. Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, USA;4. Department of Immunology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA;1. Institut national de la santé et de la recherche médicale Unit 1018, Team 5, Centre de recherche en épidémiologie et santé des populations, Hôpital Paul Brousse, Paris-Sud University and Versailles Saint-Quentin-en-Yvelines University (Paris-Ile-de-France-Ouest University), Villejuif, France;2. Department of Nephrology, Ambroise Paré University Hospital, Assistance publique – Hôpitaux de Paris, Boulogne-Billancourt/Paris, France;1. Department of Nephrology and Hypertension, Instituto de Investigacion Sanitaria Fundacion Jimenez Diaz, Universidad Autonoma de Madrid, Spain;2. RICORS2040 (Redes de Investigación Cooperativa Orientadas a Resultados en Salud), Madrid, Spain;3. Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain;4. Departamento de Medicina, Facultad de Medicina, Universidad Autónoma de Madrid, Madrid, Spain;5. Departamento de Farmacología, Universidad Autonoma de Madrid (UAM), Madrid, Spain;6. Translational Immunology, Instituto de Investigación Sanitaria del Principado de Asturias, Oviedo, Spain;7. Department of Pathology, IIS–Fundacion Jimenez Diaz, Universidad Autonoma de Madrid, Madrid, Spain
Abstract:
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  • Keywords:epidermal growth factor receptor  G2/M arrest  kidney fibrosis  partial epithelial-mesenchymal transition  ubiquitin-specific protease 11
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