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Updates on the immunopathology and genomics of severe cutaneous adverse drug reactions
Affiliation:1. Institute for Immunology and Infectious Diseases, Murdoch University, Murdoch, Australia;2. Department of Pathology, Microbiology, and Immunology, Vanderbilt University School of Medicine, Nashville, Tenn;3. Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tenn;4. Department of Dermatology, Vanderbilt University Medical Center, Nashville;5. Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tenn;6. Dokumentationszentrum schwerer Hautreaktionen Department of Dermatologie, Medical Center and Medical Faculty, University of Freiburg, Freiberg, Germany;7. Department of Pharmacology and Therapeutics, University of Liverpool, Liverpool, United Kingdom
Abstract:
Keywords:HLA  SCAR  T-cell  AGEP  SJS/TEN  DRESS  DIHS  altered peptide  AGEP"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kwrd0055"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  Acute generalized exanthematous pustulosis  CBZ"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kwrd0065"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  Carbamazepine  DHR"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kwrd0075"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  Delayed drug hypersensitivity reaction  DIHS"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kwrd0085"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  Drug-induced hypersensitivity reaction  DRESS"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kwrd0095"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  Drug reaction with eosinophilia and systemic symptoms  ERAP"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kwrd0105"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  Endoplasmic reticulum aminopeptidase  ICI"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kwrd0115"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  Immune checkpoint inhibitor  NPV"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kwrd0125"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  Negative predictive value  PPV"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kwrd0135"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  Positive predictive value  SCAR"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kwrd0145"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  Severe cutaneous adverse reaction  SCORTEN"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kwrd0155"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  Severity-of-illness score for toxic epidermal necrolysis  SJS/TEN"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kwrd0165"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  Stevens-Johnson syndrome and toxic epidermal necrolysis  TB"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kwrd0175"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  Tuberculosis  TCR"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kwrd0185"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  T-cell receptor  TRM"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kwrd0195"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  Tissue-resident memory T cell
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