Serum Uric Acid Levels and Subclinical Atherosclerosis: Results From the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) |
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| Institution: | 1. Division of Cardiology, University of New Mexico Health Sciences Center, Albuquerque, NM;2. Department of Surgery, New York University Langone Health, Long Island, Mineola, NY;3. Division of Cardiology, Ochsner Medical Center, New Orleans, LA;4. Division of Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM;5. Division of Cardiology, Houston Methodist Debakey Heart and Vascular Institute, Houston, TX;6. Division of Cardiology, Newark Beth Israel Medical Center, Newark, NJ;1. Department of Medicine, Baylor College of Medicine, Houston, TX;2. Cardiovascular Division, University of Alabama at Birmingham, Birmingham, AL;3. John T Milliken Department of Medicine, Division of Cardiovascular disease, Barnes-Jewish Hospital/Washington University in St. Louis School of Medicine, St. Louis, MO;4. Saint Louis University, Center for Abdominal Transplantation, SSM-Saint Louis University Hospital, St. Louis, MO;5. Harrington Heart & Vascular Institute, Case Western Reserve University, University Hospitals Cleveland Medical Center, Cleveland, OH;6. Division of Nephrology, Icahn School of Medicine at Mount Sinai, Mount Sinai Hospital, New York, NY;7. Division of Nephrology, University of Illinois at Chicago, Chicago, IL;8. CardioVascular Center, Tufts Medical Center, Boston, MA;9. George Washington University School of Medicine, Washington, DC.;10. Cardiology Division, NYU Langone Health and NYU School of Medicine, New York, NY;1. Department of Medicine, North Manchester General Hospital, Manchester, UK;2. Department of Medicine, Dr. Ruth K.M. Pfau Civil Hospital, Karachi, Pakistan;3. Department of Cardiology, Khyber Medical University Institute of Medical Sciences, Kohat, Pakistan;4. Department of Endocrinology, Bolan Medical University, and Health Sciences, Quetta, Pakistan;5. Department of Interventional Cardiology, Armed Forces Institute of Cardiology, Rawalpindi, Pakistan;6. Department of Medicine, Shifa International Hospital, Islamabad, Pakistan;7. Cardiovascular Analytics Group, Hong Kong, China;8. Department of Cardiology, Benazir Bhutto Hospital, Rawalpindi, Pakistan;9. Department of Medicine, Ibn e Seena Hospital, Kabul, Afghanistan |
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| Abstract: | High serum uric acid (sUA) has been associated with coronary artery calcium (CAC) and increased carotid intima-media thickness (cIMT) in people at high cardiovascular risk. However, association is unclear in apparently healthy individuals. Our study aims to evaluate association between sUA and subclinical atherosclerosis measures: CAC and increased cIMT, in apparently healthy adults enrolled in ELSA-Brasil. A total of 4096 participants without previous coronary artery disease, stroke, and use of urate-lowering drugs, underwent CAC and cIMT assessment. All analyses were stratified by sex. Serum uric acid categorized by quintiles was the exposure variable. Thorough cardiovascular risk factor evaluation was performed, and association between sUA quintiles and CAC and cIMT was analyzed by linear regression using ln(CAC + 1) and cIMT, both as continuous variables. Median age of the sample was 49.0 (44.0-56.0) years (women: 55.1%; 59.1% were white). Mean values of sUA were 6.5 ± 1.4 mg/dL for men, and 4.9 ± 1.2 mg/dL for women. The highest quintile (Q5) of sUA was independently associated with cIMT in women (beta-coefficient: 0.022; 95% CI: 0.007-0.036; P = 0.003) and men (beta-coefficient: 0.020; 95% CI: 0.002-0.038; P = 0.032). Regarding CAC, no association was found: men's Q5 (beta-coefficient: -0.142; 95% CI: -0.436 to 0.153; P = 0.347) and women's Q5 (beta-coefficient: 0.046; 95% CI: -0.152 to 0.245; P = 0.647). In this cohort, the highest sUA quintiles were independently associated with cIMT in both women and men. No association was found between sUA and the presence of CAC. |
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