纳米活性炭示踪子宫内膜癌前哨淋巴结的应用

目的 探讨纳米活性炭示踪子宫内膜癌前哨淋巴结(SLN)的可行性及有效性.方法 选择接受手术治疗的子宫内膜癌患者42例,术中选择子宫前壁、底部及后壁中点作为注射点,将示踪剂纳米活性炭注射于子宫浆膜下,追踪识别最先黑染的淋巴结.术后常规病理检测所有切除的淋巴结.结果 42例患者均首先在子宫浆膜面出现黑染,随后双侧骨盆漏斗韧带内的淋巴管着色,其中,31例(73.8%)患者盆腔内淋巴管同时着色,有30例患者识别出SLN,共计114枚.4例(9.5%)患者发生淋巴结转移,其中3例SLN转移,1例腹主动脉旁淋巴结转移患者的SLN无转移.结论 采用纳米活性炭示踪子宫内膜癌SLN具有可行性及有效性,对子宫内膜

Application of nano-activated carbon on tracing sentinel lymph node in endometrial neoplasm

Objective To explore the feasibility and effectiveness of tracing sentinel lymph node(SLN) in endometrial neoplasms using nano-activated carbon.Methods 42 patients with endometrial neoplasm who had accepted surgical treatment were enrolled.Midpoint of anterior wall,bottom and posterior wall of uterine were served as injection points,and the tracer nano-activated carbon were injected into subserosa of uterine to trace and identify the first black-stained lymph nodes during the operation.All lymph nodes removed were submitted to routine pathological testing after operation.Results Uterine serosa were found to be black-stained first in all 42 patients,followed by lymph vessels stained in bilateral pelvic funnel ligament.Among them,lymph vessels in pelvic cavity stained simultaneously in 31 cases(73.8%).SLNs were identified in 30 patients with a total number of 114.Lymphatic metastasis was occurred in 4 cases(9.5%),3 of them were SLN metastasis,and one of them with abdominal para-aortic lymph node metastasis demonstrated no SLN metastasis.Conclusion Nano-activated carbon tracing for SLN in endometrial neoplasm is feasibility and effectiveness,and has reference value for estimating lymphatic metastasis of endometrial neoplasm.