15-Deacetylsergeolide, a potent antileukemic quassinoid from Picrolemma pseudocoffea |
| |
Authors: | J Polonsky S Bhatnagar C Moretti |
| |
Abstract: | Investigation of the leaf extract of Picrolemma pseudocoffea afforded a new antineoplastic quassinoid, 15-deacetylsergeolide (3), and two known quassinoids, isobruceine B (1) and sergeolide (2). The structure of 3, which displayed strong antileukemic activity in the P-388 test system, was established through the interpretation of spectral data and chemical correlation to 2. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|