Ultrasound-guided foam sclerotherapy as a therapeutic modality in venous ulceration |
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Institution: | 1. Department of Vascular Surgery, Galway University Hospital, Galway, Ireland;2. MedStar Heart and Vascular Institute, MedStar Health, Washington, DC 20010, United States;3. Department of Vascular Surgery, Singapore General Hospital, Singapore, Singapore |
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Abstract: | ObjectivesThe objective of this systematic review and meta-analysis was to evaluate rates of ulcer healing following ultrasound-guided foam sclerotherapy (UGFS).MethodsThe MEDLINE, CENTRAL and Embase databases were used to search for relevant studies using the terms ' (sclerotherapy AND ulcer) OR (vein AND ulcer) OR (sclerotherapy AND vein)'. Heterogeneity between studies was quantified using the I2 statistic. A random effects model was used to calculate risk ratios where substantial heterogeneity was found.ResultsThe initial search yielded 8266 articles. 8 studies were included in the qualitative synthesis and 3 in the meta-analysis. Superior complete ulcer healing rates were noted in patients treated with foam sclerotherapy versus compression therapy alone (pooled OR 6.41, 95% CI = 0.3–148.2, p = 0.246, random effects method). A marked degree of heterogeneity was observed between studies (I2 = 81%).ConclusionA prospective, trial is warranted in order to determine the true merits of UGFS in the setting of venous ulceration. |
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Keywords: | Venous Ulcer Foam Sclerotherapy |
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