Association of Empirically Derived Food-Based Inflammatory Potential of the Diet and Breast Cancer: A Hospital-Based Case-Control Study |
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| Affiliation: | 1. Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), Tehran, Iran;2. Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), Tehran, Iran;1. Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY;2. Department of Surgery, University of Rochester Medical Center, Rochester, NY;1. Department of Human Oncology, University of Wisconsin School of Medicine and Public Health, Madison, WI;2. Department of Surgery, Division of Surgical Oncology, University of Wisconsin School of Medicine and Public Health, Madison, WI;1. Department of Ultrasound, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China;2. Department of Ultrasound, the Second Affiliated Hospital of Harbin Medical University, Harbin, China;3. Department of Ultrasound, the Second Affiliated Hospital of Chongqing Medical University & Chongqing Key Laboratory of Ultrasound Molecular Imaging, Chongqing, China;4. Department of Ultrasound, Shengjing Hospital of China Medical University, Shenyang, China;5. Department of Medical Ultrasound, Fudan University Shanghai Cancer Center & Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China;6. Department of Ultrasonography, Henan Provincial People′s Hospital, Zhengzhou, China;7. Department of Ultrasound, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Taiyuan, China;8. Department of Medical Ultrasound, Tongji Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, China;9. Department of Ultrasound, China-Japan Union Hospital of Jilin University, Changchun, China;10. Department of Ultrasound, the Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China;11. Department of Ultrasonography, First Affiliated Hospital of Guangxi Medical University, Nanning, China;12. Department of Medical Ultrasound, the Second Affiliated Hospital, School of Medicine, Xi''an Jiaotong University, Xi''an, China;13. Department of Ultrasound, Union Hospital of Fujian Medical University, Fujian Institute of Ultrasound Medicine, Fuzhou, China;14. Department of Ultrasound, Ruijin Hospital, Shanghai Jiaotong University, School of Medicine, Shanghai, China;15. Department of Ultrasonography, Renmin Hospital of Wuhan University, Wuhan, China;16. Department of Ultrasound, Qilu Hospital, Shandong University, Jinan, China;17. Department of Ultrasound, the Third Xiangya Hospital of Central South University, Changsha, China;18. Department of Ultrasound, the Second Affiliated Hospital of Nanchang University, Nanchang, China;19. Department of Ultrasound Medicine, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China;20. Department of Ultrasonography, the Affiliated Hospital of Guizhou Medical University, Guiyang, China;21. Department of Ultrasound, Shenzhen People''s Hospital, the Second Clinical Medical College of Jinan University, Shenzhen, China;22. Department of Ultrasound, the First Hospital of Shanxi Medical University, Taiyuan, China;23. Department of Ultrasound, the Second Hospital of Dalian Medical University, Dalian, China;1. Department of Cellular Pathology, Royal Free London Foundation Trust, London;2. Research Department of Pathology, University College London, Cancer Institute, London;1. Koc University, School of Medicine, Department of Radiation Oncology, Istanbul, Turkey;2. MD Anderson Cancer Center, Department of Radiation Oncology, Houston, TX;3. Iskenderun Gelisim Hospital, Division of Radiation Oncology, Hatay, Turkey;4. Ba?kent University Faculty of Medicine, Adana Dr Turgut Noyan Research and Treatment Center, Department of Radiation Oncology, Adana, Turkey;5. Department of Radiation Oncology, Baskent University Faculty of Medicine, Ankara, Turkey;1. University of Ljubljana, Faculty of Medicine, Ljubljana, Slovenia;2. Department of Surgical Oncology, Institute of Oncology Ljubljana, Ljubljana, Slovenia;3. Department of Medical Oncology, Institute of Oncology Ljubljana, Ljubljana, Slovenia |
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| Abstract: | BackgroundDiet may be a modifiable factor in the prevention of breast cancer (BC) by modulating inflammation. We used a food-based empirical dietary inflammatory index (FDII) to evaluate the association between FDII and odds of breast cancer in Iranian women.MethodsThe present case-control study carried out on 150 age-matched women with newly diagnosed breast cancer and controls. Data for dietary intake and anthropometric measures were collected. FDII score was developed according to participants dietary intakes of 27 pre-defined food groups. Multivariate odds ratios (OR) with 95% confidence intervals (CI) were used to investigate the association of empirically derived food-based inflammatory potential of the diet and breast cancer.ResultsThe odds ratios of BC according to quartiles of FDII score by multivariate logistic regression models indicated the FDII score was significantly associated with BC risk (OR: 2.38; 95% CI: 1.23-4.59, P trend = .04). After controlling confounders, multivariate logistic regressions remained significant which revealed in participants at the fourth quartile of FDII score chance of breast cancer was 2.8 times higher than participants in the first quartile.ConclusionsThe results of our study suggested that more pro-inflammatory diet (higher FDII scores) was associated with increased BC risk. These findings suggest that developing an effective dietary modification based on FDII may reduce risk of BC. |
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