整合素α7在非小细胞肺癌组织中的表达及临床意义

探讨整合素α7(ITGA7)在非小细胞肺癌(NSCLC)组织中的表达及与临床病理特征和预后的关系。方法回顾性分析2009年1月至2013年12月178例接受手术切除的NSCLC患者的临床病理资料。采用免疫组化SP法检测NSCLC和配对癌旁组织中ITGA7的表达水平。分析ITGA7表达与NSCLC临床病理特征以及无病生存期(DFS)和总生存期(OS)的关系。结果NSCLC组织中ITGA7的高表达率为38.2%(68/178),低表达率为61.8%(110/178);在癌旁组织中分别为23.0%(41/178)和77.0%(137/178)。ITGA7在NSCLC组织中的表达水平高于配对癌旁组织,差异有统计学意义(P=0.004)。ITGA7在NSCLC组织中的表达与分化程度和肿瘤直径有关(P<0.05),与年龄、性别、淋巴结转移和TNM分期无关(P>0.05)。NSCLC患者中,ITGA7高表达者的中位DFS为28.0(95%CI:21.7~34.3)个月,低于低表达者的35.0(95%CI:29.5~40.5)个月,差异有统计学意义(P=0.014);ITGA7高表达者中位OS为41.0(95%CI:30.5~51.5)个月,低于低表达患者的43.0(95%CI:31.9~54.1)个月,差异有统计学意义(P=0.040)。Cox多因素分析显示,ITGA7表达、分化程度和淋巴结转移是影响DFS的独立因素;分化程度和淋巴结转移是影响OS的独立因素。结论ITGA7在NSCLC组织中高表达,且与肿瘤低分化、肿瘤直径大以及不良预后有关。

The expression of integrinα7 in non-small cell lung cancer and its clinical significance

Objective To investigate the expression of integrinα7(ITGA7)in non-small cell lung cancer(NSCLC)tissues and its correlation with clinicopathological features and prognosis in NSCLC patients.Methods The clinical data of 178 NSCLC patients from November 2009 to December 2013 who received surgery were retrospectively analyzed.The expression of ITGA7 of NSCLC and paired adjacent tissues was evaluated by immunohistochemical SP medthod.The relationship between ITGA7 expression and clinicopathological features was analyzed.In addition,the impact of ITGA7 expression on the disease-free survival(DFS)and overall survival(OS)was also analyzed.Results The high expression rate of ITGA7 in NSCLC tissues was 38.2%(68/178),and low expression rate was 61.8%(110/178).The data in paired adjacent tissues was 23.0%(41/178)and 77.0%(137/178).The high expression rate of ITGA7 in NSCLC tissues was higher than that in paired adjacent tissues(P=0.004).The expression of ITGA7 was related to differentiation and diameter of tumor(P<0.05),but not to age,gender,lymph node metastasis and TNM stage(P>0.05).The median DFS in patients with high ITGA7 expression and with low ITGA7 expression was 28.0(95%CI:21.7-34.3)months and 35.0(95%CI:29.5-40.5)months(P=0.014),respectively.And the median OS was 41.0(95%CI:30.5-51.5)months in patients with ITGA7 high expression and 43.0(95%CI:31.9-54.1)months in patients with low ITGA7 expression(P=0.040).Multivariate Cox hazard ratio regression analysis revealed that ITGA7 expression,differentiation,as well as lymph node metastasis were independent factors influencing DFS.As for OS,differentiation and lymph node metastasis were independent factors.Conclusion ITGA7 is up-regulated in NSCLC tissues,and is correlated with poor differentiation,larger tumor size and worse prognosis of NSCLC.