Rheumatoid arthritis: Evolving recognition of a common disease |
| |
Institution: | 1. Oregon Health and Science University, Portland, United States;2. VA Portland Medical Center, Portland, United States |
| |
Abstract: | Rheumatoid arthritis (RA) is a highly prevalent autoimmune disease and the most common form of autoimmune inflammatory arthritis. Studies of RA pathogenesis have contributed significantly to understanding the basis for complex immune-mediated disease, identified key steps in the development of autoimmune activation and joint damage in RA, and led to the development of targeted therapies that opened up the era biologic therapy. Current studies are linking differences in gene expression to abnormalities in cellular function that will help optimize therapy for individual patients and advance the goal of personalized medicine. Our evolving understanding and current important issues in RA are highlighted. |
| |
Keywords: | Rheumatoid arthritis Early arthritis Immune pathogenesis |
本文献已被 ScienceDirect 等数据库收录! |
|