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Local magnetic delivery of adeno-associated virus AAV2(quad Y-F)-mediated BDNF gene therapy restores hearing after noise injury
Institution:1. Biological Sciences Platform, Hurvitz Brain Sciences Program, Sunnybrook Research Institute, Toronto, ON M4N 3M5, Canada;2. Physical Sciences Platform, Sunnybrook Research Institute, Toronto, ON M4N 3M5, Canada;3. Evaluative Clinical Sciences Platform, Sunnybrook Research Institute, Toronto, ON M4N 3M5, Canada;4. Department of Otolaryngology Head & Neck Surgery, Faculty of Medicine, University of Toronto, ON M5S 1A1, Canada
Abstract:
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  • Keywords:magnetic targeting  SPIONs  nanoparticles  BDNF  neurotrophins  gene therapy  hidden hearing loss  AAV2(quad Y-F)  noise-induced hearing loss  local delivery
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