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Single-dose replicating poxvirus vector-based RBD vaccine drives robust humoral and T cell immune response against SARS-CoV-2 infection
Affiliation:1. Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada;2. Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON K1H 8M5, Canada;3. Department of Medicine, The Ottawa Hospital, Ottawa, ON K1H 8L6, Canada;4. Division of Infectious Disease, Department of Medicine, University of Ottawa at The Ottawa Hospital/ Research Institute, Ottawa, ON K1H 8L6, Canada;5. Institut du Cancer de Montréal, Montréal, Québec H2X 0A9, Canada;6. Arnie Charbonneau Cancer Institute, Calgary, AB T2N 4Z6, Canada;7. Alberta Children''s Hospital Research Institute, Calgary, AB T2N 6A8, Canada;8. Department of Microbiology, Immunology and Infectious Disease, Cumming School of Medicine, University of Calgary, Calgary, AB T2T 1N4, Canada
Abstract:
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  • Keywords:vaccine  vaccinia virus  SARS-CoV-2  RBD  single dose  immune response
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