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Fungal mycobiome drives IL-33 secretion and type 2 immunity in pancreatic cancer
Affiliation:1. Department of Immunology, Roswell Park Comprehensive Cancer Center, Elm & Carlton Sts. CGP/BLSC-L5307, Buffalo, NY 14263, USA;2. Department of Biostatistics and Bioinformatics, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263, USA;3. Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA;4. Department of Cell Stress Biology, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263, USA;5. Department of Animal Resources, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263, USA;6. Department of Cytogenetics, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263, USA;7. Genomics Shared Resource, Department of Cancer Genetics & Genomics, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263, USA;8. Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA;9. Department of Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263, USA;10. Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA;11. Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA;12. Collaborative Innovation Center for Cancer Medicine, State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center, Guangzhou 510060, China
Abstract:
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  • Keywords:IL-33  type 2 immune response  innate lymphoid cells  ILC2  TH2  fungal mycobiome  Kras  PDAC  intratumor-microbiome  anti-fungal therapy
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