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Ablation of the endoplasmic reticulum stress kinase PERK induces paraptosis and type I interferon to promote anti-tumor T cell responses
Institution:1. Department of Immunology, H. Lee Moffitt Cancer Center, Tampa, FL 33612, USA;2. California Northstate University, Elk Grove, CA 95757, USA;3. Department of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center, Tampa, FL 33612, USA;4. Department of Pathology, H. Lee Moffitt Cancer Center, Tampa, FL 33612, USA;5. Department of Tumor Biology, H. Lee Moffitt Cancer Center, Tampa, FL 33612, USA;6. Department of NeuroOncology, H. Lee Moffitt Cancer Center, Tampa, FL 33612, USA;7. Department of Obstetrics and Gynecology, University of Chicago, Chicago, IL 60637, USA;8. Department of Obstetrics and Gynecology, Weill Cornell Medicine, New York, NY 10065, USA;9. Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10065, USA;10. Department of Pediatrics, Georgia Cancer Center, Augusta University, Augusta, GA 30912, USA
Abstract:
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  • Keywords:tumor immunity  PERK  unfolded protein responses  type I IFN  immunogenic cell death
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