A Comparison of the Oncological Outcomes After Breast-Conserving Surgery With or Without Latissimus Dorsi Myocutaneous Flap Reconstruction for Breast Cancer |
| |
| Affiliation: | 1. Department of Breast and Endocrine Surgery, Osaka International Cancer Institute, Osaka, Japan;2. Department of Breast Surgery, Mie University Hospital, Mie, Japan;3. Department of Plastic and Reconstructive Surgery, Osaka International Cancer Institute, Osaka, Japan;1. Department of Breast and Thyroid Surgery, Huanggang Central Hospital of Hubei Province, Huanggang City, Hubei Province, China;2. Department of Breast and Thyroid Surgery,Chongqing Hospital of Traditional Chinese Medicine, Chongqing City, China;1. DeWitt Daughtry Family Department of Surgery, Division of Surgical Oncology, University of Miami School of Medicine, Miami, FL;2. DeWitt Daughtry Family Department of Surgery, University of Miami School of Medicine, Miami, FL;3. DeWitt Daughtry Family Department of Surgery, Division of Plastics and Reconstructive Surgery, University of Miami School of Medicine, Miami, FL;1. Department of Gynaecology and Obstetrics, Faculty of Medicine, Federal University of Goiás, Goiânia, Brazil;2. Department of Gynaecology and Obstetrics, Faculty of Medicine, Federal University of São Paulo, São Paulo, Brazil;3. Graduate Program in Health Sciences, Faculty of Medicine, Federal University of Goiás, Goiânia, Brazil;4. Discipline of Oncology, Department of Radiology and Oncology, Faculty of Medicine, University of Sao Paulo, Sao Paulo, Brazil;5. Laboratory of Molecular Genetics, Center for Translational Research in Oncology (LIM24), Cancer Institute of Sao Paulo, Sao Paulo, Brazil;1. Department of Breast Surgery, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, 310006, China;3. The First Clinical College, Zhejiang Chinese Medical University, Hangzhou, 310053, China;1. Assosciate Member of Radiology, Moffitt Cancer Center, Tampa, FL;2. Associate Member of Cancer Physiology, Moffitt Cancer Center, Tampa, FL;3. Post-doctoral Fellow, Quantitative Imaging Core, Moffitt Cancer Center, Tampa, FL;4. Associate Member of Radiology, Moffitt Cancer Center, Tampa, FL;5. Assistant Member of Radiology, Moffitt Cancer Center, Tampa, FL;6. Associate Member of Pathology, Moffitt Cancer Center, Tampa, FL;7. Associate Member of Breast Surgery, Moffitt Cancer Center, Tampa, FL;8. Senior Member of Breast Surgery, Moffitt Cancer Center, Tampa, FL;9. Associate Member of Breast Surgery, Moffitt Cancer Center, Tampa, FL;10. Senior Member of Radiation Oncology, Moffitt Cancer Center, Tampa, FL;11. Assistant Member of Radiation Oncology, Moffitt Cancer Center, Tampa, FL;1. Department of Surgery, Mayo Clinic, Phoenix, AZ;2. Mayo Clinic Alix School of Medicine, Scottsdale, AZ;3. Department of Research, Mayo Clinic, Phoenix, AZ;4. Division of Surgical Oncology & Endocrine Surgery, Mayo Clinic, Phoenix, AZ;5. Division of Hematology/Oncology, Mayo Clinic, Phoenix, AZ;6. Department of Laboratory Medicine and Pathology, Mayo Clinic, Phoenix, AZ |
| |
| Abstract: | BackgroundThere is little information on the oncological outcomes of breast-conserving surgery (BCS) with immediate reconstruction using a latissimus dorsi myocutaneous flap (LDMF) for breast cancer compared with BCS alone.Patients and MethodsWe conducted a retrospective cohort study from a single institution comparing the margin positivity rates after initial surgery, re-excision rates, and local recurrence (LR) between BCS with immediate LDMF reconstruction (n = 145) and BCS alone (n = 1040) performed from 2012 to 2017 for newly diagnosed stage 0-3 breast cancer.ResultsThe positive rates of surgical margin after initial surgery were significantly lower in the BCS with LDMF group than in the BCS alone group (4.1 vs. 10.8%; P = .006). There were no marked differences in the re-excision rates between the BCS with LDMF and BCS alone groups (P = .1). At a median follow-up of 61 months, the surgical method (BCS with LD vs. BCS alone) was not associated with the LR-free survival after adjusting for various clinicopathologic factors (P = .8).ConclusionOur findings suggest that BCS with immediate LDMF reconstruction is oncologically safe for breast cancer compared with BCS alone. However, further studies are needed. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
